Results 91 to 100 of about 89,500 (322)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Managing Ethical Requirements Elicitation

, 2023
The process of Requirements Elicitation (RE) demands from a software development team the need to communicate and engage with a variety of stakeholders, for numerous purposes regarding many aspects of the project. The aim is to translate the needs of the “customer” into accurate and actionable requirements.
Siakas, Errikos, Rahanu, Harjinder, Loveday, Joanna, Georgiadou, Elli, Siakas, Kerstin, Ross, Margaret   +5 more
openaire   +3 more sources

Transforming natural language into controlled language in requirements elicitation: a pre-conceptual-schema-based conceptual synthesis

Revista Facultad de Ingeniería Universidad de Antioquia, 2014
During  the  requirements  elicitation  process,  a  group  of  analysts  and stakeholders  identify,  capture,  and  integrate  requirements.  Textual  or graphic   descriptions   capturing   the   most   relevant   concepts   from   the   domain of a ...
Bell Manrique Losada, Carlos Mario Zapata Jaramillo   +1 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Formal Requirements Elicitation with FRET [PDF]

FRET is a tool for writing, understanding, formalizing and analyzing requirements. Users write requirements in an intuitive, restricted natural language, called FRETISH, with precise, unambiguous meaning.
Giannakopoulou, Dimitra, Mavridou, Anastasia, Pressburger, Thomas, Rhein, Julian, Schumann, Johann, Shi, Nija   +5 more
core   +1 more source

In search of requirements analyst characteristics that influence requirements elicitation effectiveness: a quasi-experiment [PDF]

, 2012
Context: Elicitation effectiveness depends on non-wellunderstood analyst?s skills and abilities. Identifying which analysts? characteristics have stronger influence on elicitation may help to improve requirements quality. Objective: Identify the analysts?
Aranda López King, Alejandrina, Dieste Tubio, Oscar, Juristo Juzgado, Natalia   +2 more
core  

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Revisiting Requirements Elicitation Techniques

International Journal of Computer Applications, 2013
The importance of Requirements Engineering (RE) has been well recognized by the research community in the last decade. There is no doubt to say that requirements phase is the foundation of the entire Software Development Life Cycle (SDLC) on which the entire software is built.
S. K. Pandey, Shreta Sharma
openaire   +1 more source