Results 121 to 130 of about 18,010,417 (271)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Lingnan Gardeners Newsletter (No. 10) = 嶺南彩園通訊 (第10期)
, 2015 White Dews 白露https://commons.ln.edu.hk/ln_gardeners_newsletter/1009/thumbnail ...
Lingnan Gardeners, Kwan Fong Cultural Research and Development Programme, Lingnan University
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SEEDS: the OARDC Research Enhancement Competitive Grants Program [PDF]
, 2008 Ohio Agricultural Research and Development Center
core +3 more sources
RESEARCH AND DEVELOPMENT IN NURSING [PDF]
Journal of Advanced Nursing, 1992 openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Biological reviews of important Cambodian fish species, based on fishbase 2004 Volume 1 [PDF]
This document is a review of all the information published worldwide about ten fish species that contribute significantly to Cambodian fishery resources.Freshwater fish, Cambodia, Channa striata, Channa micropeltes, Barbonymus altus, Barbonymus ...
Baran, E. +5 more
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Research and researcher development
Research and researcher development training seminar for ESR ...
openaire +1 more source