Results 101 to 110 of about 3,733,869 (258)

Potential Refractive Error Due to Axial Displacement of Intraocular Lenses with Clinically Relevant Compression Diameters

Clinical Ophthalmology
Andrew Maxwell,1,* James S Marotta,2,* Maddi McGough,2,* Neaz Almir,2,* Sandy Valenzuela,2,* Alesha LaFleur,2,* Marcia D Ong,2,* Kamal K Das,2,* Doug Wensrich2,*1InSight Vision Center, California Eye Institute, Fresno, CA, USA; 2Research &amp ...
Maxwell A, Marotta JS, McGough M, Almir N, Valenzuela S, LaFleur A, Ong MD, Das KK, Wensrich D   +8 more
doaj  

ARTEMISIA: a mechanistic study of a novel Janus kinase 1 inhibitor to advance molecular understanding and precision medicine in asthma

Respiratory Research
Background Patients with uncontrolled asthma despite the use of inhaled corticosteroids (ICS), may have a variety of biological pathways driving their airway inflammation. Londamocitinib (AZD4604), a selective, inhaled, Janus kinase 1 inhibitor, has been
Davinder Paul Singh Dosanjh, Erika Darrah, Tina Jellesmark Jensen, Zala Jevnikar, Alese Halvorson, Mathias Cardner, Rod Hughes, Sarah S. Grant, Adam Platt, Chris E. Brightling   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Virtual Teams for New Product Development – An Innovative Experience for R&D Engineers [PDF]

New interaction tools such as internet allow companies to gain valuable input from research and development (R&D) engineers via virtual teams. Consequently, engineers also get more expertise in diminutive time frames.
Ahmed, Shamsuddin, Taha, Zahari, Ale Ebrahim, Nader   +2 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Endogenous R&D Spillovers and Industrial Research Productivity [PDF]

This paper explores the implications of a simple model of learning and innovation by firms. In this model R&D spillovers are partly determined by firms, rather than by the given economic environment.
James D. Adams
core  

Coronaviruses: A patent dataset report for research and development (R&D) analysis. [PDF]

Data Brief, 2020
Machuca-Martinez F, Amado RC, Gutierrez O.   +2 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Impact of R&D Investment On Productivity - New Evidence Using Linked R&D-LRD Data [PDF]

This paper uses confidential Census longitudinal microdata to examine the association between R&D and productivity for the period 1972.1985. These data allow for significant improvements in measurement and model specification, yielding more precise ...
Donald Siegel, Frank R. Lichtenberg
core  

GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice

Nature Communications
An early driver of Type 2 diabetes mellitus (T2D) is ectopic fat accumulation, especially in the liver, that impairs insulin sensitivity. In T2D, GLP-1R/GCGR dual-agonists reduce glycaemia, body weight and hepatic steatosis.
Rhianna C. Laker, Shaun Egolf, Sarah Will, Louise Lantier, Owen P. McGuinness, Charles Brown, Nicholas Bhagroo, Stephanie Oldham, Kyle Kuszpit, Alex Alfaro, Xidan Li, Taewook Kang, Giovanni Pellegrini, Anne-Christine Andréasson, Sarina Kajani, Sadichha Sitaula, Martin R. Larsen, Christopher J. Rhodes   +17 more
doaj   +1 more source