Results 111 to 120 of about 3,733,869 (258)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Virtual Collaborative R&D Teams in Malaysia Manufacturing SMEs [PDF]

This paper presents the results of empirical research conducted during March to September 2009. The study focused on the influence of virtual research and development (R&D) teams within Malaysian manufacturing small and medium sized enterprises (SMEs ...
Ahmed, Shamsuddin, Abdul Rashid, Salwa Hanim, Taha, Zahari, Ale Ebrahim, Nader   +3 more
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Tax incentives for R&D [PDF]

A long-standing concern surrounding the performance of the UK economy is its perceived failure to maintain the same technological pace as its competitors.
Rachel Griffith, David Sandler, John Van Reenen   +2 more
core  

Fruit crops, 1980: a summary of research [PDF]

, 1980
Performance of selected apple cultivars on semi-standard rootstocks in southern Ohio / David C. Ferree, Donald A. Chandler, and John C. Schmid -- Influence of summer pruning and alar on growth, flowering, and fruit set of Jerseymac apple trees / D.
Ferree, D. C., Hall, F. R., Funt, R. C., Reichard, D. L., Krueger, H. R., Crassweller, R. M., Chandler, D. A., Stang, E. J., Brazee, R. D., Ellis, M. A., Schmid, J. C., Cahoon, G. A., Fox, R. D.   +12 more
core  

Enhanced Thompson sampling by roulette wheel selection for screening ultralarge combinatorial libraries

Journal of Cheminformatics
Chemical space exploration has gained significant interest with the increasing availability of building blocks, enabling the creation of ultralarge virtual libraries containing billions or trillions of compounds.
Hongtao Zhao, Eva Nittinger, Melissa A. Yu, Symon Gathiaka, W. Patrick Walters, Christian Tyrchan   +5 more
doaj   +1 more source

Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications

Frontiers in Immunology
Regulatory T cells (Tregs) are central to immune homeostasis and controlling inflammation through multiple mechanisms, however, recent discoveries and advances in technology reveal that Tregs exert a diverse array of functions beyond mere ...
Bat-Erdene Jugder, Eunchong Park, Lijuan Du, Lijuan Du, Chetan Jawale, Nikolay Popov, Zengli Guo, Zengli Guo, Kyle J. Bednar, Tatiana Ort   +9 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Buying and Selling Research and Development Services, 1997 to 2002 [PDF]

Research and development is a crucial activity in the innovation process. Not every firm is in a position to overcome constraints to R&D, such as costs.
Mohnen, Pierre, Rosa, Julio, Rose, Antoine   +2 more
core