Results 61 to 70 of about 3,733,869 (258)

Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies

Respiratory Research, 2020
Background Navafenterol (AZD8871) is a novel, long-acting, dual-pharmacology (muscarinic receptor antagonist and β2−adrenoceptor agonist) molecule in development for chronic obstructive pulmonary disease and asthma. Methods These two phase I, randomised,
Victor Balaguer, Muna Albayaty, Eulalia Jimenez, Ulrika Wählby-Hamrén, Carol Astbury, Beatriz Seoane, Marie-Pierre Malice, Alejhandra Lei, Ajay Aggarwal, Ioannis Psallidas   +9 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Sheep research and development, 1966

, 1966
Factors associated with the ram influence on ewe fertility / C. F. Parker and D. S. Bell -- Observations on shrinkage in lambs -- Stocking rate and companion grazing on Kentucky Bluegrass-Trefoil pastures / R. W.
Judy, J. K., Bell, D. S., VanStavern, B. D., Parker, C. F., Pounden, W. D., Van Keuren, R. W., Redman, D. R., Grimshaw, R. H., Trapp, A. L., Hamdy, A. H.   +9 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Privatization, Public R&D Policy, and Private R&D Investment in China's Agriculture [PDF]

Private R&D is a major source of innovation and productivity growth in agriculture worldwide. This paper examines trends and determinants of agricultural R&D in China.
Hu, Ruifa, Jin, Yanhong H., Huang, Jikun, Pray, Carl E., Liang, Qin   +4 more
core  

DPIRD grains research and development (R&D) stakeholder update 2023

, 2023
The Grains R&D (Research and Development) Stakeholder Update was developed to showcase the industry-leading work delivered by the Grains Research and Industry Development team at the Department of Primary Industries and Regional Development (DPIRD) in ...
Department of Primary Industries and Regional Development, Western Australia
core   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Elarekibep, an inhaled anti-IL-4 receptor alpha Anticalin, in moderate-to-severe asthma: a randomized, placebo-controlled phase 2a study (APATURA)

Respiratory Research
Background The pro-inflammatory cytokines interleukin (IL)-4 and IL-13 and their cognate receptor IL-4 receptor-alpha are key targets for asthma therapy.
Tania Hugo, Andrew R Harper, Jacob Leander, Philip Gardiner, Robert Palmér, Pål Lundin, David Bock, Xiao-Hong Zhou, Irina Bondarenko, Steve Burns, Erol Wiegert, Mary F Fitzgerald, David R Close, David J Keeling, Hitesh Pandya, Maria G Belvisi, Paul M O’Byrne   +16 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Knowledge Production of 'R' and 'D' [PDF]

Many studies investigate the relationship between R&D expenditures as an input and patents as an intermediate product or output of a knowledge production function.
Thorwarth, Susanne, Czarnitzki, Dirk, Kraft, Kornelius   +2 more
core