Results 71 to 80 of about 3,733,869 (258)

Integrating R&D and marketing in new product development [PDF]

, 2011
R&D - marketing integration is considered to be a critical activity within New Product Development (NPD). A theoretical framework for the study of R&D - marketing integration levels developed by Gupta et al (1986) is one of the most widely cited R&D ...
Fain, Nusa, Duhovnik, Joze, Kline, Mihael   +2 more
core   +3 more sources

Novel Influenza Vaccines: From Research and Development (R&D) Challenges to Regulatory Responses. [PDF]

Vaccines (Basel), 2023
He X, Zhang T, Huan S, Yang Y.
europepmc   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Evaluation of reinforcement learning in transformer-based molecular design

Journal of Cheminformatics
Designing compounds with a range of desirable properties is a fundamental challenge in drug discovery. In pre-clinical early drug discovery, novel compounds are often designed based on an already existing promising starting compound through structural ...
Jiazhen He, Alessandro Tibo, Jon Paul Janet, Eva Nittinger, Christian Tyrchan, Werngard Czechtizky, Ola Engkvist   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A research and development (R&D) roadmap for broadly protective coronavirus vaccines: Setting a path to address coronavirus threats. [PDF]

Vaccine, 2022
Moore KA, Osterholm MT, Lackritz EM, Poland GA.   +3 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes

Scientific Reports, 2019
Bleomycin hydrolase (BLMH) is a well-conserved cysteine protease widely expressed in several mammalian tissues. In skin, which contains high levels of BLMH, this protease is involved in the degradation of citrullinated filaggrin monomers into free amino ...
Rebecca Riise, Lina Odqvist, Johan Mattsson, Susan Monkley, Suado M. Abdillahi, Christian Tyrchan, Daniel Muthas, Linda Fahlén Yrlid   +7 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system

Communications Biology
Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays.
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Müllers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Löfmark, Carina Ämmälä, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilén   +17 more
doaj   +1 more source