Results 51 to 60 of about 160,180 (288)

Initiative to establish Research Data Alliance moves forward [PDF]

Eos, Transactions American Geophysical Union, 2012
With the amount of scientific data being gathered growing exponentially—due to the increasing number of sensor networks, scientific instruments, computer models, and other tools—there are enormous scientific opportunities but also significant challenges, including how to effectively share research data within and across scientific communities.
openaire   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The research data alliance – A global collaboration forum to tackle data challenges

, 2021
ABSTRACT / INTRODUCTIONThe Research Data Alliance (RDA) [1], a community-driven initiative with the goal of building the social and technical infrastructure to enable open sharing and re-use of data, currently has over 11,000 members - including data scientists, librarians, researchers, funders, policy makers - from more than 140 countries [2].
Kethers, Stefanie, Treloar, Andrew
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Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Towards standardised cross-sectoral agreements for data depositing and data access in Trusted Research Environments: streamlined contracting to advance public benefit research. 

International Journal of Population Data Science
Objective  Trusted Research Environments (TREs) rely on Data Contributor Agreements (DCAs) and Data Access Agreements (DAAs) to bind organisations to terms and conditions in place to protect data.
Rachel Brophy, Cassie Smith, Andy Boyd, Pan UK Data Governance Steering Group   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Scientific Knowledge Mobilization: Co-evolution of Data Products and Designated Communities

International Journal of Digital Curation, 2015
Digital data are accumulating rapidly, yet issues relating to data production remain unexamined. Data sharing efforts in particular are nascent, disunited and incomplete.
Karen S. Baker, Ruth E. Duerr, Mark A. Parsons   +2 more
doaj   +1 more source

Introducing the FAIR Principles for research software

Scientific Data, 2022
Research software is a fundamental and vital part of research, yet significant challenges to discoverability, productivity, quality, reproducibility, and sustainability exist.
Michelle Barker, Neil P. Chue Hong, Daniel S. Katz, Anna-Lena Lamprecht, Carlos Martinez-Ortiz, Fotis Psomopoulos, Jennifer Harrow, Leyla Jael Castro, Morane Gruenpeter, Paula Andrea Martinez, Tom Honeyman   +10 more
doaj   +1 more source

The Research Data Alliance

, 2016
To appear in the proceedings of Astronomical Data Analysis Software and Systems XXV (ADASS XXV), a conference held 25-29 October 2015 at Sydney, Australia. Edited by N. P. F. Lorente, & K. Shortridge (San Francisco: ASP)
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