Results 121 to 130 of about 14,201,106 (332)

The benefit of textile design research to the textile designer. [PDF]

open access: yes, 2010
If Textile Designers do not embark on and utilise textile research we will be left in a ‘sole less’ vacuum. The following article aims to show the benefit of textile design research to the textile designer. Textile design is increasingly complex, and
Montgomery, Bruce
core  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Are we there yet? Insights to support the use of reflective practice methods for explorative practice-led doctoral research into real-world design problems [PDF]

open access: yes, 2009
This paper concerns the use of design thinking in practice-led doctoral design research. It examines methodological appropriateness for research through design.
Spencer, Nick, Young, Robert
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Criticality meets sustainability: Constructing critical practices in design research for sustainability [PDF]

open access: yes, 2008
Sustainability requires a wider awareness of the changing conditions for design today – rather than focused solely on preserving nature or conserving energy, per se, this opens up for challenging assumptions about relations between design and society and
Mazé, Ramia
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Titanium-doped sapphire laser research and design study [PDF]

open access: yes
Three main topics were considered in this study: the fundamental laser parameters of titanium-doped sapphire, characterization of commercially grown material, and design of a tunable, narrow-linewidth laser.
Moulton, Peter F.
core   +1 more source

Alterplinarity – ‘Alternative Disciplinarity’ in Future Art and Design Research Pursuits [PDF]

open access: yes, 2011
Contemporary design is typified by fluid, evolving patterns of practice that regularly traverse, transcend and transfigure historical disciplinary and conceptual boundaries.
Bremner, Craig, Rodgers, Paul
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

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