Results 81 to 90 of about 34,823,597 (367)

Reflecting theology by a generic model of research designs? Impulses from religious didactics

open access: yesHTS Teologiese Studies/Theological Studies, 2021
A look at history showed that theology always has to face contemporary demands in terms of its scientific character. At present, processes of pluralisation and secularisation challenge the existence of theology at universities not only against the ...
Martin Rothgangel, Ulrich Riegel
doaj   +1 more source

Challenge course : research, design, and plan [PDF]

open access: yes, 2013
Ball State University offers an extensive variety of recreational and leadership opportunities but no challenge course. Administrators have determined that there is a need and interest in the challenge course facility and its curriculum.
Edenfield, Jessica M.
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Surveying the factors that influence maintainability: research design [PDF]

open access: yes, 2005
We want to explore and analyse design decisions that influence maintainability of software. Software maintainability is important because the effort expended on changes and fixes in software is a major cost driver.
Hordijk, Wiebe, Wieringa, Roel
core   +2 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

Legal Culture and empirical research: improving the socio-legal character of the sociology of law

open access: yesOñati Socio-Legal Series, 2022
The aim of this special issue is to present empirical research outcomes and theoretical works that use the concept of legal culture to characterize the approach of the sociology of law.
Carlo Pennisi
doaj  

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Championing Research Through Design in HRI [PDF]

open access: yesarXiv, 2019
One of the challenges in conducting research on the intersection of the CHI and Human-Robot Interaction (HRI) communities is in addressing the gap of acceptable design research methods between the two. While HRI is focused on interaction with robots and includes design research in its scope, the community is not as accustomed to exploratory design ...
arxiv  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

A triangulation approach for design research [PDF]

open access: yes, 2009
Triangulation has been adopted in social science in the study of the same phenomenon through applying and combining several data sources, research methods, investigators, and theoretical schemes.
Duffy, Alex H.B.   +2 more
core  

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