Results 71 to 80 of about 10,894,164 (293)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A visiting endowed chair to support mentoring and career coaching for early career researchers

open access: yesJournal of Clinical and Translational Science, 2023
Lourdes E. Soto de Laurido   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Évolution de l’environnement alpin

open access: yesRevue de Géographie Alpine, 2008
The way the Alpine environment will evolve in the 21st century depends upon climate change. This could lead to climates never before seen in the Alps, resulting in a major and lasting environmental crisis.
Philippe Schoeneich, Carmen de Jong
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Relationship between Perception of Educational-Research Environment and Research Self-efficacy and Academic Achievement of Students of Mashhad University of Medical Sciences [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2015
Introduction: Academic achievement of students is one of the most important indicators for assessment of higher education. The purpose of this study was to investigate the relationship between perception of educational-research environment and research ...
Ezatollah ghadampour   +2 more
doaj  

Changes in the Alpine environment

open access: yesRevue de Géographie Alpine, 2008
The way the Alpine environment will evolve in the 21st century depends upon climate change. This could lead to climates never before seen in the Alps, resulting in a major and lasting environmental crisis.
Philippe Schoeneich, Carmen de Jong
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Designing a Questionnaire to Measure Threats and Opportunities of E-Learning and Determining its Psychometric properties [PDF]

open access: yesInterdisciplinary Journal of Virtual Learning in Medical Sciences, 2014
Introduction: E-learning environment is one of the most common learning environments in the information era. Therefore, recognizing its associated threats and opportunities is of the highest priority.
Hossein Khoshrang   +2 more
doaj  

RESEARCH OBJECT AS MECHANISM FOR ENSURING RESEARCH EXPERIMENT REPRODUCIBILITY WITHIN VIRTUAL RESEARCH ENVIRONMENT

open access: yesTASK Quarterly, 2017
A Research Object (RO) is defined as a semantically rich aggregation of resources that bundles together essential information relating to experiments and investigations. This information is not limited merely to the data used and the methods employed to
MARCIN KRYSTEK   +4 more
doaj   +1 more source

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