Results 81 to 90 of about 10,894,164 (293)

CSRE: a speech research environment

2nd International Conference on Spoken Language Processing (ICSLP 1992), 1992
CSRE (The Canadian Speech Research Environment) is a comprehensive, microcomputer-based system designed to support speech research using IBM/AT-compatible micro-computers. CSRE provides a powerful, low-cost facility in support of speech research, using mass-produced and widely available hardware.
Donald G. Jamieson, Ketan Ramji, Issam Kheirallah, Terrance M. Nearey   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

GATT AND THE ENVIRONMENT: POLICY RESEARCH NEEDS [PDF]

This paper is a brief review of current problems in which trade and environmental issues intersect. After a statement of these problems, it focuses on some recent empirical research and future research needs of special relevance to agricultural ...
Harold, Courtney, Runge, C. Ford
core   +1 more source

Measuring the Global Research Environment: Information Science Challenges for the 21st Century [PDF]

, 2005
“What does the global research environment look like?” This paper presents a summary look at the results of efforts to address this question using available indicators on global research production.
Anderson, Caryn, Bammer, Gabriele
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

QUALITY IN TERMS OF COST EFFICIENCY [PDF]

Revista Română de Statistică, 2010
The studies based on using selective research are one of the maininstruments in the strategy building process at the managing level of academic facilities and collecting the data in the most effective way possible is one of the main problems that this ...
Vasile Alecsandru STRAT
doaj  

Using Virtual Research Environments in Agro-Environmental Research

, 2020
Tackling some of the grand global challenges, agro-environmental research has turned more and more into an international venture, where distributed research teams work together to solve complex research questions. Moreover, the interdisciplinary character of these challenges requires that a large diversity of different data sources and information is ...
Lokers, R.M., Knapen, M.J.R., Candela, L., Hoek, S.B., Meijninger, W.M.L.   +4 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source