Results 161 to 170 of about 4,970,902 (314)

Insights from the evaluations of the NIH Centers for Accelerated Innovation and Research Evaluation and Commercialization Hubs programs. [PDF]

J Clin Transl Sci, 2022
Anderson BJ, Leonchuk O, O'Connor AC, Shaw BK, Walsh AC.   +4 more
europepmc   +1 more source

Research Evaluation to Increase Impact

Research evaluation, undertaken throughout the life of the research activity, is an important tool for research managers. When correctly implemented, research evaluation can help to increase the success of existing and future research projects and ...
Templeton, Deborah J.
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Responsible research evaluation: integrating quality, leadership, and integrity in national systems. The case of Peru. [PDF]

Front Res Metr Anal
Millones-Gómez PA, Castillo-Nunez JPS, Paucca-Calla KJ, Minchón-Medina CA, Castro-Delgado VL, Sotelo-Llancari S, Ignacio-Punin C, Rodríguez-Salazar DY, Urrutia-Baca VH.   +8 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Beyond cumulative impact: the he-index and a volume-normalized efficiency metric for research evaluation. [PDF]

Front Res Metr Anal
Laimon M.
europepmc   +1 more source

Streamlining Trauma Research Evaluation With Advanced Measurement (STREAM) Study: Implementation of the PROMIS Toolbox Within an Orthopaedic Trauma Clinical Trials Consortium. [PDF]

J Orthop Trauma, 2022
Carlini AR, Collins SC, Staguhn ED, Frey KP, O'Toole RV, Archer KR, Obremskey WT, Agel J, Kleweno CP, Morshed S, Weaver MJ, Higgins TF, Bosse MJ, Levy JF, Wu AW, Castillo RC, METRC.   +16 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Evaluation of Norwegian International Climate and Forest Initiative Support to Civil Society

The Evaluation Department at Norad, in collaboration with CMI and Vista Analyse, has conducted an evaluation of the Norwegian International Climate and Forest Initiative's support to civil society.
Williams, Aled, Sagmo, Tove
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source