FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Evaluation of Norad’s use of knowledge in portfolio management [PDF]
A few years ago, Norad published its strategy towards 2030 and was reorganised to better fit its responsibility for managing an increasing share of Norwegian development aid.
Tjønneland, Elling +4 more
core
Developing Future Leaders in Health Assessment Research: Evaluation of interRAI's inSPIRe Program. [PDF]
Healthc Manage ForumWeir J +8 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Correction: Enabling transparent research evaluation: A method for historical RCR retrieval using public NIH metadata. [PDF]
PLoS OneHaupt F +3 more
europepmc +1 more source
Research Evaluation Alongside Clinical Treatment in COVID-19 (REACT COVID-19): an observational and biobanking study. [PDF]
BMJ Open, 2021 Burke H +14 more
europepmc +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Evaluation of Norwegian International Climate and Forest Initiative Support to Civil Society [PDF]
The Evaluation Department at Norad, in collaboration with CMI and Vista Analyse, has conducted an evaluation of the Norwegian International Climate and Forest Initiative's support to civil society.
Williams, Aled, Sagmo, Tove
core
Enabling transparent research evaluation: A method for historical RCR retrieval using public NIH metadata. [PDF]
PLoS OneHaupt F +3 more
europepmc +1 more source