Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A Comparison of Approaches and Instruments for Evaluating a Geological Sciences Research Experiences Program [PDF]
This article describes a study in which changes in knowledge of science and attitudes regarding science among participants in a summer Research Experiences for Undergraduates (REU) program were examined. It was discovered that existing survey instruments
Olga Jarrett +2 more
core
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Qualitative telephone interviews: Strategies for success [PDF]
The use of the telephone in qualitative interviews is discouraged by traditionalists who view it as an inferior data collection instrument. However these claims have not been supported by empirical evidence and qualitative researchers who have used and ...
Farooq, Muhammad Bilal
core +1 more source
The Wide Field Spectrograph (WiFeS): Performance and Data Reduction
This paper describes the on-telescope performance of the Wide Field Spectrograph (WiFeS). The design characteristics of this instrument, at the Research School of Astronomy and Astrophysics (RSAA) of the Australian National University (ANU) and mounted ...
Bloxham, Gabe +12 more
core +1 more source
The analysis of Ethiopian traditional music instrument through indigenous knowledge (kirar, masinko, begena, kebero and washint/flute) [PDF]
This article aims to explore and analytics about Ethiopian traditional music instrument through indigenous knowledge (kirar, masinko, Begena, kebero and washint/flute).
Sinshaw, Girmaw Ashebir
core
Measuring enrichment: The assembly and validation of an instrument to assess student self-beliefs in CS1 [PDF]
Educational research shows that self-beliefs can have profound influences on learning behavior and achievement. It follows, then, that beliefs about the nature of programming aptitude (mindset) and the way individuals perceive themselves as programmers ...
Ghinea, G, Scott, M
core +2 more sources
High-Speed Image Velocimetry System for Rainfall Measurement
In this paper, a new image-based disdrometer is developed to survey the movement of free falling raindrops. The proposed high-speed image velocimetry (HSIV) system comprises a high-speed camera mounted on a lens with long depth of field, a backlight ...
Chih-Yen Chen +5 more
doaj +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source

