Results 91 to 100 of about 2,124,373 (330)

A proposal for measuring the benefits of policy-oriented social science research: [PDF]

This paper addresses the problem of how to measure the benefits of policy-oriented social science research. It argues that social science research promotes economic efficiency in three different ways—it fosters efficiency in the public sector both ...
Park, Donghyun
core  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Understanding Qualitative Research Methodology: A Systematic Review [PDF]

E-Journal of Humanities, Arts and Social Sciences
As novice researchers and supervisors, the researchers of the current study have noticed that many postgraduate students encounter challenges in understanding qualitative research methodology.
David Seetsa Makateng , Ntsoaki Teresa Mokala   +1 more
doaj   +1 more source

Replication Markets: Results, Lessons, Challenges and Opportunities in AI Replication [PDF]

arXiv, 2020
The last decade saw the emergence of systematic large-scale replication projects in the social and behavioral sciences, (Camerer et al., 2016, 2018; Ebersole et al., 2016; Klein et al., 2014, 2018; Collaboration, 2015). These projects were driven by theoretical and conceptual concerns about a high fraction of "false positives" in the scientific ...
arxiv  

Measuring the benefits of social science research: [PDF]

This paper addresses two questions: The first is "What are the benefits of social science research?"; the second is "How should they be measured?" The response to the first is that, as with research in the physical sciences, the benefits should be ...
Smith, Vincent H.
core  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Impact of social context on human facial and gestural emotion expressions

iScience
Summary: Humans flexibly adapt expressions of emotional messages when interacting with others. However, detailed information on how specific parts of the face and hands move in socio-emotional contexts is missing.
Raphaela Heesen, Mark A. Szenteczki, Yena Kim, Mariska E. Kret, Anthony P. Atkinson, Zoe Upton, Zanna Clay   +6 more
doaj  

Dealing with Big Data [PDF]

arXiv, 2016
This book chapter attempts to counter anxieties in the humanities and social science about the role of big data in research by focusing on approaches which, by being firmly grounded in the traditional values of disciplines, enhance existing methods to produce fruitful research.
arxiv  

Integrated Approach in “Social Research of Science” as a Methodological Problem

Procedia - Social and Behavioral Sciences, 2015
AbstractSociology of scientific knowledge (SSK) is a study of science as a social activity, especially dealing with the social conditions and effects of science and with the social structures and processes of scientific activity. The theorists of Sociology of Scientific Knowledge consider sociological factors as influencing all beliefs in science ...
openaire   +2 more sources

Cultural representations of mental illness in contemporary Japan [PDF]

, 2014
This paper presents the results of a research project aimed at studying the cultural representations of mental illness and related interventions models in contemporary Japan, and providing the basis for a comparison between Japanese and Italian mental ...
Bucci, Fiorella
core