Results 61 to 70 of about 2,405,022 (374)

OVERVIEW OF SOCIAL SCIENCE RESEARCH METHODOLOGY IN HORTICULTURE [PDF]

open access: yesHortScience, 1991
During this presentation, several basic issues related to survey research will be introduced and illustrated. First several issues related to sampling will be considered. These will include how to determine sample size, where to obtain a sampling frame, how to compute error rates, and how to estimate costs associated with sampling.
openaire   +2 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

COVID-19 test-to-stay program for K-12 schools: Opt-in versus opt-out consent model

open access: yesiScience
Summary: The Centers for Disease Control and Prevention promoted the Test-to-Stay (TTS) program to facilitate in-person instruction in K-12 schools during COVID-19.
Anton Ivanov   +8 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Assessing the impact of armed conflict on the progress of achieving 17 sustainable development goals

open access: yesiScience
Summary: With global armed conflicts reaching a 30-year high in 2023, understanding their impact on the progress of Sustainable Development Goals (SDGs) is crucial.
Di Wang   +3 more
doaj   +1 more source

The impact of the COVID-19 pandemic on enrollment in undergraduate health-related studies in Spain

open access: yesBMC Medical Education, 2023
The aim of this study was to determine whether the pandemic has reinforced the choice of pursuing health-related bachelor’s degrees, and to identify underlying factors that could contribute to that impact.
Jaume-Miquel March-Amengual   +11 more
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Do You See what I See? Tracking the Perceptual Beliefs of Robots

open access: yesiScience, 2020
Summary: Keeping track of others' perceptual beliefs—what they perceive and know about the current situation—is imperative in many social contexts. In a series of experiments, we set out to investigate people's ability to keep track of what robots know ...
Sam Thellman, Tom Ziemke
doaj   +1 more source

A methodological approach to evaluate elderly-robot interactions [PDF]

open access: yes, 2018
The relevance in the study of interaction between elderly and robots may depend on the choice of activities that robots can be developed to perform and the assessment of their impact and importance for older people.
Gonçalves, Paulo   +4 more
core  

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

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