Results 81 to 90 of about 2,405,022 (374)

Integration of cognitive tasks into artificial general intelligence test for large models

iScience
Summary: During the evolution of large models, performance evaluation is necessary for assessing their capabilities. However, current model evaluations mainly rely on specific tasks and datasets, lacking a united framework for assessing the ...
Youzhi Qu, Chen Wei, Penghui Du, Wenxin Che, Chi Zhang, Wanli Ouyang, Yatao Bian, Feiyang Xu, Bin Hu, Kai Du, Haiyan Wu, Jia Liu, Quanying Liu   +12 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Prioritized neural processing of social threats during perceptual decision-making

iScience
Summary: Emotional signals, notably those signaling threat, benefit from prioritized processing in the human brain. Yet, it remains unclear whether perceptual decisions about the emotional, threat-related aspects of stimuli involve specific or similar ...
M. El Zein, R. Mennella, M. Sequestro, E. Meaux, V. Wyart, J. Grèzes   +5 more
doaj   +1 more source

Sarcopenia and associated factors according to the EWGSOP2 criteria in older people living in nursing homes: a cross-sectional study

BMC Geriatrics, 2022
Background In 2018, the European Working Group on Sarcopenia in Older People (EWGSOP2) updated the original definition of sarcopenia, establishing new criteria to be used globally.
Anna Escribà-Salvans, Javier Jerez-Roig, Miriam Molas-Tuneu, Pau Farrés-Godayol, Pau Moreno-Martin, Ester Goutan-Roura, Helena Güell-Masramon, Jordi Amblàs-Novellas, Dyego Leandro Bezerra de Souza, Dawn A. Skelton, Miriam Torres-Moreno, Eduard Minobes-Molina   +11 more
doaj   +1 more source

Critical realism in empirical research: employing techniques from grounded theory methodology

International Journal of Social Research Methodology, 2018
Whilst critical realism (CR) is becoming recognised as a significant meta-theory for the social sciences, there is little guidance on how to produce research which is consistent with its ontological and epistemological assumptions.
E. Hoddy
semanticscholar   +1 more source

Revisión bibliográfica. Lesiones en el deporte: bíceps braquial y voleibol [PDF]

, 2014
Objective: The main objective of this review was to assess the prevalence of lesions in the brachial biceps in volleyball players, as well as review the different prevention measures and procedures that are used in this treatment myocardial structure ...
Díaz Sotero, Silvia
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Using PLS path modeling in new technology research: updated guidelines

Industrial management & data systems, 2016
Purpose – Partial least squares (PLS) path modeling is a variance-based structural equation modeling (SEM) technique that is widely applied in business and social sciences.
J. Henseler, Geoffrey S. Hubona, P. A. Ray   +2 more
semanticscholar   +1 more source

A proposal for measuring the benefits of policy-oriented social science research: [PDF]

This paper addresses the problem of how to measure the benefits of policy-oriented social science research. It argues that social science research promotes economic efficiency in three different ways—it fosters efficiency in the public sector both ...
Park, Donghyun
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source