Results 81 to 90 of about 1,919,142 (346)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Methodological Nationalism in the Social Sciences: Consequences for Social Science Research

open access: yesMigracijske i etničke teme, 2011
Social scientists are becoming increasingly aware of the fact that human society cannot and should not be equated with the “national society”, an imagined aggregate of social relations within the boundaries of nation-states. The first decade of the 21st century was marked by the discussion on methodological nationalism, i.e.
Simona Kuti, Saša Božić
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Sample Size Determination Techniques for Behavioral Sciences Research

open access: yesJournal of Humanities and Social Sciences Mahasarakham University, 2023
The purposes of this article are to inform readers about. - 1) how to gain better understanding regarding the sample size techniques for behavioral science research, 2) know how to determine the sample size for classical behavioral sciences ...
Rungson Chomeya, Sombat Tayraukham
doaj  

OVERVIEW OF SOCIAL SCIENCE RESEARCH METHODOLOGY IN HORTICULTURE [PDF]

open access: yesHortScience, 1991
During this presentation, several basic issues related to survey research will be introduced and illustrated. First several issues related to sampling will be considered. These will include how to determine sample size, where to obtain a sampling frame, how to compute error rates, and how to estimate costs associated with sampling.
openaire   +1 more source

L'entretien de recherche avec des journalistes Editorial [PDF]

open access: yes, 2012
International audienceThis is true of our first issue on interviews, a methodology which cuts across the fields of human and social sciences. We invite you to read it and consider what this particular research approach yields from real people in ...
Demers, François   +3 more
core   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Reshaping Academic Practice and Relationships within the Department Of Plant Sciences [PDF]

open access: yes, 2007
At the University of Cambridge, a research and development project concerned with teaching and learning in small-group tutorials has been initiated in Department of Plant Sciences.
Johnstone, Keith   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy