Results 121 to 130 of about 5,285,257 (310)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A live attenuated NS1-deficient vaccine candidate for cattle-origin influenza A (H5N1) clade 2.3.4.4.b viruses

npj Vaccines
Avian Influenza viruses (AIVs) present a public health risk, especially with seasonal vaccines offering limited protection. AIV H5N1 clade 2.3.4.4b has caused a multi-state outbreaks in the United States (US) poultry and cattle since March 2024, raising ...
Ahmed Mostafa, Chengjin Ye, Ramya S. Barre, Vinay Shivanna, Reagan Meredith, Roy N. Platt, Ruby A. Escobedo, Mahmoud Bayoumi, Esteban M. Castro, Nathaniel Jackson, Anastasija Cupic, Aitor Nogales, Timothy J. C. Anderson, Adolfo García-Sastre, Luis Martinez-Sobrido   +14 more
doaj   +1 more source

Integrating ayurvedic medicine into cancer research programs part 2: Ayurvedic herbs and research opportunities. [PDF]

J Ayurveda Integr Med, 2023
Arnold JT.
europepmc   +1 more source

Physical Education Matters: A Full Report [PDF]

, 2008
Examines the quantity and quality of California's physical education programs, compliance with requirements, and resources. Summarizes research on the benefits of PE and effective strategies to improve PE programs.

core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Integrating oral pre-exposure prophylaxis delivery in primary care family planning clinics: a pragmatic, stepped-wedge, cluster-randomised trial

The Lancet Primary Care
Summary: Background: Integrating pre-exposure prophylaxis (PrEP) delivery in family planning settings might offer an efficient platform to reach women at increased risk for HIV. This study aimed to prospectively assess the effectiveness of a health-care
Kenneth K Mugwanya, MBChB, Daniel Matemo, MPH, Allison Meisner, PhD, Torin Schaafsma, MS, Jennifer Morton, MPH, Cynthia Wandera, BSN, Valarie Kemunto, BSN, Irine Cherotich, MSc, Stephen Odhiambo, Dip, Mercy Bii, Dip, Beatrice Oduor, Dip, Esther Achieng, Dip, Tecy Oyombra, Dip, David Owaga, BSc, Kristin M Beima-Sofie, PhD, ProfMD Jared M Baeten, PhD, John Kinuthia, MMed   +16 more
doaj   +1 more source

TEACHING, RESEARCH, AND EXTENSION PROGRAMS AT PREDOMINANTLY BLACK LAND-GRANT INSTITUTIONS [PDF]

Teaching/Communication/Extension/Profession,
Williams, Thomas T., Williamson, Handy, Jr.   +1 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The congressionally directed medical research programs' Ovarian Cancer Academy: a new approach to training in biomedical research. [PDF]

J Clin Transl Sci, 2022
Wyatt TR, Stepleman L, Coleman T, Robinson L, Wylie K, Levine DA, Maihle NJ.   +6 more
europepmc   +1 more source

Vulnerable Youth: Federal Mentoring Programs and Issues [PDF]

, 2018
[Excerpt] The purpose of contemporary, structured mentoring programs is to reduce risks by supplementing (but not supplanting) a youth’s relationship with his or her parents. These programs are administered by mostly adult volunteers who are recruited by
Fernandes-Alcantara, Adrienne L
core   +1 more source