Results 101 to 110 of about 69,816,536 (306)

HRCI’s 2022 position paper – using data for better health research [PDF]

open access: yes, 2022
Our 2022 Position Paper is all about data and its importance to health research. The themes contained within are a priority for our member charities and have also been guided by the outcomes of the Irish Health Research Forum events, which HRCI runs. The
Health Research Charities Ireland, /
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Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Multivariate trend comparisons between autocorrelated climate series with general trend regressors [PDF]

open access: yes
Inference regarding trends in climatic data series, including comparisons across different data sets as well as univariate trend significance tests, is complicated by the presence of serial correlation and step-changes in the mean.
Timothy Vogelsang, Ross McKitrick
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Manifesto for medical research [PDF]

open access: yes, 2015
The MRCG want to ensure there is a dynamic medical research environment in Ireland. Ensuring priority investment for medical research will help to deliver patient care, public health service transformation and economic and enterprise development.
Medical Research Charities Group
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Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Future Research and Trends in Ultra-Wideband Indoor Tag Localization

open access: yesIEEE Access
Ultra-wideband (UWB) signals are widely used for indoor tag localization because of their high accuracy, wide bandwidth, and low power consumption. The diversity and breadth of research in the field of UWB-indoor tag localization can be confusing for new
Gita Indah Hapsari   +3 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

open access: yesFEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng   +8 more
wiley   +1 more source

IFLA Trend Report 2021 Update

open access: yes, 2022
Will we see the importance of virtual services and spaces reinforced, or will there be an analogue backlash? Will we see further political polarisation and undermining of expertise, or will information literacy finally be recognised and valued?
International Federation of Library Associations and Institutions (IFLA)
core   +1 more source

A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots

open access: yesFrontiers in Medicine
BackgroundOptic atrophy (OA) is primarily caused by damage to the retinal pathway system, including widespread degeneration of retinal ganglion cells and axons, leading to visual impairment and blindness.
Liyuan Wang   +14 more
doaj   +1 more source

GDPR and health research: stakeholder voices. Data protection and health research - what does the legislation mean for patients, the public and the research community? Report and recommendations. [PDF]

open access: yes, 2018
This report presents the proceedings of the Irish Health Research Forum on November 14th 2018 focusing on data protection legislation and health research, and the implications for patients, the public and researchers.
Medical Research Charities Group
core  

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