Results 81 to 90 of about 69,816,536 (306)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Trend estimation deals with the characterization of the underlying, or long–run, evolution of a time series. Despite being a very pervasive theme in time series analysis since its inception, it still raises a lot of controversies.
Proietti, Tommaso
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Comment on: Trends in research related to high myopia from 2010 to 2019: a bibliometric and knowledge mapping analysis [PDF]
International Journal of Ophthalmology, 2022 Yuh-Shan Ho
doaj +1 more source
Global trends in tertiary lymphoid structures: a bibliometric analysis from 2014 to 2023
Frontiers in ImmunologyAim and backgroundTertiary lymphoid structures (TLS) are increasingly recognized for their role in immunity. Despite growing interest, a systematic bibliometric analysis of TLS-related research has been lacking.
Yiwen Bao +14 more
doaj +1 more source
Optimal monetary policy under low trend inflation [PDF]
In the monetary policy literature it is commonly assumed that trend inflation is zero, despite overwhelming evidence that zero inflation is neither empirically relevant nor a practical objective for central bank policy.
Tiziano Ropele, Guido Ascari
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Comment on: Bibliometric analysis of glaucoma-related literature based on SCIE database: a 10-year literature analysis from 2009 to 2018 [PDF]
International Journal of Ophthalmology, 2023 Yuh-Shan Ho
doaj +1 more source
ElectrochemistryThe Center for Advanced Battery Collaboration (ABC) was established at the National Institute for Materials Science with the support of COI-NEXT, Japan Science and Technology Agency (JST).
Kei NISHIKAWA +11 more
doaj +1 more source
Spurious regression under broken trend stationarity [PDF]
We study the phenomenon of spurious regression between two random variables when the generating mechanism for individual series follows a stationary process around a trend with (possibly) multiple breaks in its level and slope.
Daniel Ventosa-Santaularia +1 more
core