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Tissue-resident memory T cells in the urogenital tract
Nature Reviews Nephrology, 2022Our understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within peripheral tissues at key pathogen entry sites. These tissue-resident memory T (TRM) cells can respond promptly to an infection without the need for migration, proliferation or differentiation.
Loreto Parga-Vidal +3 more
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Tissue-Resident Memory T Cells in Allergy
Clinical Reviews in Allergy & ImmunologyTissue-resident memory T (TRM) cells constitute a distinct subset within the memory T cell population, serving as the vanguard against invading pathogens and antigens in peripheral non-lymphoid tissues, including the respiratory tract, intestines, and skin.
Bojin, Long +8 more
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Resident memory T cells: Runx and hide
Science Immunology, 2018The transcription factor Runx3 enhances the differentiation and survival of CD8 + resident memory T cells; enhancing Runx3 expression in responding T cells could lead to better therapies for infection and cancer.
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Peripheral tissue surveillance and residency by memory T cells
Trends in Immunology, 2013T cell immunity has long been described in terms of two circulating memory populations. Central memory T (T(CM)) cells migrate between the secondary lymphoid organs and are capable of mounting a recall proliferative response on pathogen re-encounter, whereas effector memory T (T(EM)) cells traffic between blood and extralymphoid compartments for ...
Thomas, Gebhardt +3 more
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Resident memory T cells are a Notch above the rest
Nature Immunology, 2016Notch signaling promotes the maintenance of lung-resident CD8+ memory T cells that are transcriptionally poised for rapid effector responses but have heightened expression of inhibitory receptors, suggestive of tight regulation.
Sathi, Wijeyesinghe, David, Masopust
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Behavior and Function of Tissue-Resident Memory T cells
2012Our understanding of memory T cell function in mice and men is to date in large part restricted to the behavior of circulating memory T cells. Emerging evidence, however, suggests that in addition to such systemic memory T cell populations, a separate population of locally confined memory T cells is generated at former sites of antigen encounter. Here,
Silvia, Ariotti +2 more
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Tissue-Resident Memory T Cells in Cancer Immunosurveillance
Trends in Immunology, 2019Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in protecting against viral and bacterial infections is well established ...
Simone L, Park +2 more
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Unveiling the role of resident memory T cells in psoriasis
Journal of Leukocyte BiologyAbstract Psoriasis is a chronic inflammatory skin disease characterized by periods of remission and relapse. In this pathology, keratinocytes, dendritic cells, and different subpopulations of T cells are critical to developing psoriatic lesions.
Juan Saavedra-Almarza +7 more
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Tissue resident memory T cells in respiratory infections
Current Opinion in Infectious DiseasesPurpose of review We review the latest evidence that respiratory tissue resident memory T (T RM ) cells are key to local and immediate adaptive immunity to bacterial and viral infections of the respiratory tract and the implication for the design
Karen N, McCarthy, Kingston H G, Mills
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Resident memory T cells develop regional dialects
Nature Immunology, 2023Nicholas J. Maurice, Stephen C. Jameson
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