Results 51 to 60 of about 524,865 (248)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Using Literature Review to Inform an Anti-Oppressive Approach to Community Safety

Engaged Scholar Journal
Literature review is a common piece of any scholarly research, but it is rare for it to be squarely at the centre of a community-based project.
Julie Chamberlain, Stacy Cardigan Smith, Dagen Perrott   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Case report: Liver Transplantation in a highly dependent Down Syndrome patient

Transplantation Reports, 2020
Despite the malformations commonly associated with Down Syndrome, the average life expectancy of individuals nowadays may reach 60-70 years of age. With these increased survival rates, the spectrum of diseases reported in these patients has been growing,
Marina Guitton Rodrigues, Paula Marcela Vilela Castro, Tiago Careli de Almeida, Bruno Carrijo Cunha, Fernanda Ribeiro Danziere, Francisco Antonio Sergi Filho, Beimar Edmundo Zeballos Sempertegui, Juan Rafel Branez, Leonardo Toledo Mota, Marcelo Perosa de Miranda, Regina Gomes dos Santos, e Tércio Genzini   +11 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Cochlear implants: our experience and literature review

International Archives of Otorhinolaryngology, 2012
Summary Introduction: Cochlear Implants are important for individuals with severe to profound bilateral sensorineural hearing loss. Objective: Evaluate the experience of cochlear implant center of Otorhinolaryngology through the
Mariane Barreto Brandão Martins, Francis Vinicius Fontes de Lima, Ronaldo Carvalho Santos Júnior, Arlete Cristina Granizo Santos, Valéria Maria Prado Barreto, Eduardo Passos Fiel de Jesus   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Dermatite Infeciosa Associada a Infeção por HTLV-1 no Adulto: Difícil Diagnóstico e Importante Manejo Clínico

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2017
A dermatite infeciosa é uma dermatite grave, crónica e recidivante associada ao vírus linfotrópico de células T humano tipo 1 (HTLV-1). Embora a maioria dos casos descritos tenha início na infância, casos de dermatite infeciosa em adultos tem sido ...
Priscila Silva Correia, Fernanda Cabral, Gabriela Higino de Souza, Miguel Barrella Neto, Daniel Lago Abadia, Igor Brum Cursi   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source