Results 41 to 50 of about 90,434 (287)

Analisa Sisa Klor dan Candida Albicans Serta Keluhan Kesehatan Mahasiswa Fakultas Ilmu Keolahragaan di Kolam Renang Sejahtera Club Chain Universitas Negeri Medan Tahun 2014 [PDF]

, 2014
Swimming pool is one of the public places which is liked by all and a place where people can easily catch up with many disease. The joint use of swimming pool and poor hygiene can cause negative effects for health of the students from Faculty of Sport ...
marsaulina, I. (irnawati), naria, E. (evi), yani, I. D. (isna)   +2 more
core  

Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomized trial. [PDF]

, 2010
BACKGROUND: Because both micronutrients and antimicrobial peptides protect against diarrhea, we looked for an effect on intestinal antimicrobial peptide gene expression during a randomized controlled trial of multiple micronutrient (MM) supplementation ...
Bevins, Charles L, Dhaliwal, Winnie, Jagatiya, Poonam, Kelly, Paul, Khanam, Moriam, Ndulo, Namwiinga, Sanderson, Ian R, Shawa, Tamara, Simuyandi, Michelo   +8 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Removal of disinfection by-product precursors by coagulation and an innovative suspended ion exchange process [PDF]

, 2015
This investigation aimed to compare the disinfection by-product formation potentials (DBPFPs) of three UK surface waters (1 upland reservoir and 2 lowland rivers) with differing characteristics treated by (a) a full scale conventional process and (b ...
Jarvis, Peter, Jefferson, Bruce, Judd, Simon J., Metcalfe, David, Rockey, Chris   +4 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Optimization of Chlorine Injection Dosage in Water Distribution Networks Using a Genetic Algorithm [PDF]

آب و فاضلاب, 2011
Water supply management, both in terms of quality and quantity, is facing serious problems due to growing municipal, industrial, and agricultural demands.
Masoud Tabesh, Behrad Azadi, Abbas Rouzbahani   +2 more
doaj  

HUBUNGAN ANTARA SISA CHLOR BEBAS DENGAN MPN COLIFORM PADA AIR MINUM PDAM KECAMATAN KARANGANYAR [PDF]

, 2007
air adalah salah satu kebutuhan pokok manusia. Pengolahan air diperlukan untuk mendapatkan air sesuai dengan kualitas yang diinginkan. Keputusan Menteri Kesehatan RI No 907/MENKES/SK/VII/2002 menyatakan bahwa pemeriksaan air meliputi pemeriksaan kualitas
HARMASTUTI, SIWI NURWENDYAH
core  

Reverse osmosis membrane composition, structure and performance modification by bisulphite, iron(III), bromide and chlorite exposure [PDF]

, 2016
Reverse osmosis (RO) membrane exposure to bisulphite, chlorite, bromide and iron(III) was assessed in terms of membrane composition, structure and performance.
Cortina Pallás, José Luís, Ferrer, Olga, Gibert Agulló, Oriol   +2 more
core   +2 more sources