Results 131 to 140 of about 6,667,826 (304)
Alzheimer's disease image classification based on enhanced residual attention network.
With the increasing number of patients with Alzheimer's Disease (AD), the demand for early diagnosis and intervention is becoming increasingly urgent. The traditional detection methods for Alzheimer's disease mainly rely on clinical symptoms, biomarkers,
Bairui Gong +4 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The effect of vibratory stress on the welding microstructure and residual stress distribution [PDF]
, 2001 Previous studies have suggested that weld microstructure may be modified by the presence of static stresses. In this investigation, vibratory stress was applied to mild steel specimens while they were being welded to observe its effect on the residual ...
Waddell, A.J. +2 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of University Medical & Dental College, 2020 Introduction: Oto-endoscopy is a new and latest introduction in the middle ear and mastoid surgery. Its application has not yet gained popularity in Pakistan and our study is first of its kind in Pakistan to evaluate the utility of oto-endoscope in canal
Salahuddin Ayubi
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Characterization of bathtub distributions via percentile residual life functions [PDF]
In reliability theory and survival analysis, many set of data are generated by distributions with bathtub shaped hazard rate functions. Launer (1993) established several relations between the behaviour of the hazard rate function and the percentile ...
Alba M. Franco-Pereira +2 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Intralesional ALA-PDT for residual extramammary Paget's disease: a case report
Frontiers in SurgeryBackgroundExtramammary Paget's disease (EMPD) is a rare cutaneous malignancy often associated with positive surgical margins and high local recurrence rates.
Jianhua Huang +9 more
doaj +1 more source