Results 91 to 100 of about 125,543 (299)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
"Estimation and Testing for Unit Root Processes with GARCH (1, 1) Errors: Theory and Monte Carlo Evidence" [PDF]
Least squares (LS) and maximum likelihood (ML) estimation are con-sidered for unit root processes with GARCH (1, 1) errors.
Michael McAleer, W. K. Li, Shiqing Ling
core
Alexandria Engineering JournalThis article introduces a novel extension of the log Kumaraswamy distribution, termed Marshall Olkin log Kumaraswamy (MOLkw). The mathematical and statistical characteristics of the suggested distribution are constructed, encompassing explicit ...
Naif Alotaibi
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Revista Caatinga, 2008 Random regression models (RRM) allows considering heterogeneous residual variances to describe the growth for each age. However, this feature increases the number of parameters to be estimated in the maximization likelihood function process.
Patrícia Tholon +1 more
doaj
Scientific ReportsThe purpose of this study was to model and optimize the removal of methylene blue using a novel magnetic chitosan-carboxymethyl cellulose/multiwalled carbon nanotubes and to identify the most significant parameters influencing the adsorption efficiency ...
Mahmood Yousefi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
SymmetryAs a powerful tool for characterizing the time-evolution behavior of dynamic systems with delay characteristics, the parameter estimation problem for uncertain delay differential equations has always been a research hotspot in the field of uncertain statistics.
Han Wang, Zhiqiang Zhang, Haiyan Shi
openaire +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source