Results 61 to 70 of about 125,543 (299)

A New Family of Truncated Nadarajah-Haghighi-G Properties with Real Data Applications

Tikrit Journal of Administrative and Economic Sciences, 2023
In this paper, the [0,1] truncated Nadarajah Haghighi- G family is introduced, and some of its statistical properties such as expansion of its PDF are derived. In addition, quantile function, survival function, hazard rate function, reversed hazard rate
Khalaf H. Al-Habib , Mundher A. Khaleel, Hazem Al-Mofleh   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Flexible Approach to Quantile Regression Modeling With Unit Burr‐XII‐Poisson and Its Applications to Cancer, Chemotherapy, and Energy Data

Engineering Reports
This article introduces the unit‐Burr XII‐Poisson (UBXIIP) distribution, a flexible model for bounded data in the unit interval. Unlike many existing alternatives, the UBXIIP offers enhanced versatility in modeling unit‐domain phenomena.
Mustapha Muhammad, Gaber Sallam Salem Abdalla, Abdoulie Faal, Ehab M. Almetwally, Mohammed Elgarhy   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The Bds Test As A Test For The Adequacy Of A Garch(1,1) Specification: A Monte Carlo Study [PDF]

, 2004
In this study we examine the widely used Brock, Dechert and Scheinkman (BDS) test when applied to the logarithm of the standardized residuals of an estimated GARCH(1,1) model as a test for the adequacy of this speciÞcation.
Pittis, Nikitas, Guglielmo Maria Caporale, Ntantamis, C, Pantelidis, T, Pittis, N, Pantelidis, Theologos, Caporale, GM, Caporale, Guglielmo Maria, Ntantamis, Christos   +8 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Maximum Likelihood Associative Memories

, 2013
International audienceAssociative memories are structures that store data in such a way that it can later be retrieved given only a part of its content -- a sort-of error/erasure-resilience property.
Michael Rabbat, Rabbat, Michael, Gripon, Vincent, Vincent Gripon   +3 more
core   +3 more sources