Results 51 to 60 of about 2,606,220 (288)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

An integrated approach to the determination and consequences of residual stress on the fatigue performance of welded aircraft structures [PDF]

, 2005
Although residual stress in welded structures and components has long been known to have an effect on their fatigue performance, access to reliable, spatially accurate residual stress field data has been limited.
Edwards, Lyndon, Fitzpatrick, Michael E., Yapp D, Yapp, D, Sinclair, I, Fitzpatrick, M. E., Sinclair, I., Edwards L, Sinclair I, Edwards, L, Zhang, X, Zhang, Xiang, Irving, P. E., Irving, Phil E., Fitzpatrick M E, Fitzpatrick ME, Irving PE, Zhang X, Irving P E, Yapp, David   +19 more
core   +1 more source

Explainable machine learning and software tool for the residual compressive and tensile strength of recycled aggregate concrete at elevated temperatures

Materials Today Sustainability
The lack of reliable code-based predictive models for the residual properties of recycled aggregate concrete (RAC) at elevated temperatures hinders its use in fire-prone applications.
Abdelrahman Abushanab, Vanissorn Vimonsatit   +1 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effects of Fine-Grained Particles and Sodium Chloride Solution on Physical Properties and Residual Strength of Granite Residual Soils: An Experimental Study

Advances in Civil Engineering
Stability analyses of earth structures composed of granite residual soils (GRSs) are consistently essential, particularly under significant vibrational loading.
Chen Fang, Ying Li, Yang Shi, Lei Liu, Baodong Xing, Zhaoyu Wang   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The effect of weathering process to determination of residual shear strength of clay shale with triaxial multi-stage system [PDF]

, 2017
The slope failure on clay shale with many joints under a layer of tuff breccia shortly after stress release due to cutting activity have triggered the need to investigate clay shale residual shear strength.
Simatupang, Pintor T., Nazir, Ramli, Masyhur, Irsyam, Alatas, Idrus M.   +3 more
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