Results 71 to 80 of about 348,093 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Significant Influence on Residual Bending Strength by Cracks Generation During Grinding of Ceramics

Chinese Journal of Mechanical Engineering
Any product must undergo precise manufacturing before use. The damage incurred during the manufacturing process can significantly impact the residual strength of the product post-manufacturing.
Jinshuo Zhang, Tianyi Sui, Bin Lin, Bingrui Lv, Jingming Li, Jingguo Zhou   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Effect of Crack Pattern on the Residual Strength of Ceramics After Quenching

, 2011
The physical mechanisms between residual strength and crack characteristic of ceramics after water-quenching are studied by statistically measuring the cracks in ceramic sheet.
李炜, Liu BY, 周志亮, 邵颖峰, Shao, YF (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China, 许向红, 张跃   +6 more
core   +1 more source

Analysis of Strength Degradation of Q235 Corroded Steel Based on Pitting Evolution

Taiyuan Ligong Daxue xuebao
Proposes To evaluate the strength degradation behavior of corroded steel with pitting evolution, an in-situ pitting evolution method is achieved by ABAQUS software combined with Python program according to pit statistics on steel matrix surfaces at ...
Benzhao FU, Ruizong LIN, Yun ZHAO, QI GUO, Zeyan WU   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Development of a Design Formula for Estimating the Residual Strength of Corroded Stiffened Cylindrical Structures

Journal of Marine Science and Engineering
This paper develops a novel design formula to estimate the residual strength of corroded stiffened cylindrical structures. It extends a previously established ultimate strength formulation for intact cylinders by introducing a corrosion-induced strength ...
Sang-Hyun Park, Byoungjae Park, Sang-Rai Cho, Sung-Ju Park, Kookhyun Kim   +4 more
doaj   +1 more source

Experimental investigation of high temperature effect on Slag based alkali activated concrete and ordinary concrete

Electronic Journal of Structural Engineering, 2020
Effect of elevated temperature on residual mechanical properties of slag based alkali activated concrete (SAC) was compared with Ordinary Portland cement concrete (OPC) when subjected to temperature up to 900 ° C. SAC was prepared using sodium hydroxide
Sonal Thakkar, Urmil Dave, Jay Patel
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source