Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202 [PDF]
, 2018 CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at ...
Bangcharoenpaurpong O. +8 more
core +2 more sources
Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame
Molecules, 2013 The potential for dynamic chirality of an azapeptide nitrogen was examined by substitution of nitrogen for the α-carbon of the aspartate residue in the sweetener S,S-aspartame.
Samir H. Bouayad-Gervais +1 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Effect of charged lipids on the ionization behavior of glutamic acid containing transmembrane helices [PDF]
, 2020 Transmembrane proteins make up critical components of living cells. Protein function can be greatly impacted by the charged state of its respective components, the side chains of amino acid residues.
Nunn, Brooke
core +2 more sources
Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles. [PDF]
, 2014 Methods for the construction of thiazolo-, thiazino-, and thiazepino-2H-indazoles from o-nitrobenzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1°-aminothioalkanes are reported.
Farber, Kelli M +2 more
core +2 more sources
Vertical migration of some herbicides through undisturbed and homogenized soil columns
Orbital: The Electronic Journal of Chemistry, 2008 A laboratory experiment was conducted by using three herbicides, two from dinitroaniline group and one from thiocarbamate group to know their degree of downward movement (leachability) through soil columns and their contribution in ground water ...
Md. Wasim Aktar +3 more
doaj
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Decomposition and nutrient release of leguminous plants in coffee agroforestry systems. [PDF]
, 2011 Leguminous plants used as green manure are an important nutrient source for coffee plantations, especially for soils with low nutrient levels.
ANDERSON J.D. +37 more
core +4 more sources
Analytical Chemistry, 2016 Cross-linking mass spectrometry (XL-MS) has become a powerful strategy for defining protein–protein interactions and elucidating architectures of large protein complexes.
Craig B. Gutierrez +5 more
semanticscholar +1 more source