Results 41 to 50 of about 648,030 (307)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Thermal processing of Khoot coal and characterization of obtained solid and liquid products

Mongolian Journal of Chemistry, 2014
On 21st January 2015, the abstract of this paper was replaced with the correct abstract.The coal of Khoot deposit have been investigated and determined the technical characteristics, elemental and petrographical maceral compositions.
S Batbileg, B Purevsuren, Ya Davaajav, J Namkhainorov   +3 more
doaj   +1 more source

Effect of charged lipids on the ionization behavior of glutamic acid containing transmembrane helices [PDF]

, 2020
Transmembrane proteins make up critical components of living cells. Protein function can be greatly impacted by the charged state of its respective components, the side chains of amino acid residues.
Nunn, Brooke
core   +2 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Mineral Concentrations in Different Types of Honey Originating from Three Regions of Continental Croatia

Foods
Honey has been recognized as a reliable indicator of environmental quality because of honeybees’ intense foraging activity, which brings them into contact with many persistent organic pollutants around the hive. In this study, four types of honey (meadow,
Ivana Tlak Gajger, Damir Pavliček, Višnja Oreščanin, Ivana Varenina, Marija Sedak, Nina Bilandžić   +5 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

A pain-causing and paralytic ant venom glycopeptide

iScience, 2021
Summary: Ants (Hymenoptera: Formicidae) are familiar inhabitants of most terrestrial environments. Although we are aware of the ability of many species to sting, knowledge of ant venom chemistry remains limited.
Samuel D. Robinson, Lucas Kambanis, Daniel Clayton, Hannes Hinneburg, Leo Corcilius, Alexander Mueller, Andrew A. Walker, Angelo Keramidas, Sameer S. Kulkarni, Alun Jones, Irina Vetter, Morten Thaysen-Andersen, Richard J. Payne, Glenn F. King, Eivind A.B. Undheim   +14 more
doaj   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Single phase extraction method for determination of dithianon residues in fruits and vegetables using LC ESI (-) MS/MS

Scientific Reports
Dithianon is a non-systemic fungicide, applied in some agricultural products. Dithianon residues in food cause health problems for humans so it is recommended to be analyzed in fruits and vegetables.
Esmail Elsayed Aboshanab, Mahmoud Hamdy Abdelwahed, Sanaa A. M. El-Sawi, Mostafa M. Emara, Ahmed A. Omran   +4 more
doaj   +1 more source

Facile Synthesis of the Naturally Cytotoxic Triterpenoid Saponin Patrinia-Glycoside B-II and Its Conformer

Molecules, 2013
The first chemical synthesis of the natural triterpenoid saponin Patrinia-glycoside B-II, namely oleanolic acid 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-gluco-pyranosyl-(1→3)]-α-L-arabinopyranoside, has been accomplished in a linear 11-step sequence 11 with 9.
Li Ren, Yong-Xiang Liu, Dan Lv, Mao-Cai Yan, Han Nie, Yang Liu, Mao-Sheng Cheng   +6 more
doaj   +1 more source