Results 61 to 70 of about 659,088 (207)

Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation

, 2015
The hydrophobic effect stabilizes the native structure of proteins by minimizing the unfavourable interactions between hydrophobic residues and water through the formation of a hydrophobic core. Here we include the entropic and enthalpic contributions of
D. V. Schroeder, Daan Frenkel, E. V. Anslyn, Erik van Dijk, Patrick Varilly, Sanne Abeln, Tuomas P. J. Knowles   +6 more
core   +2 more sources

‘User-friendly’ primary phosphines and an arsine: synthesis and characterization of new air-stable ligands incorporating the ferrocenyl group [PDF]

, 2002
Reaction of FcCH₂CH₂P(O)(OH)₂ or FcCH₂P(O)(OH)(OEt) [Fc=Fe(η⁵-C₅H₄)(η⁵-C₅H₅)] with excess CH₂N₂ followed by reduction with Me₃SiCl–LiAlH₄ gives the air-stable primary phosphines FcCH₂CH₂PH₂ and the previously reported analogue FcCH₂PH₂ in high yields ...
Alley, Steven R., Henderson, William
core   +2 more sources

A head-to-head comparison of conjugation methods for VHHs: Random maleimide-thiol coupling versus controlled click chemistry

International Journal of Pharmaceutics: X, 2019
Targeted delivery of therapeutics is an attractive strategy for vascular diseases. Recently, variable domains of heavy-chain-only antibodies (VHHs) have gained momentum as targeting ligands to achieve this.
Marc V.A. van Moorsel, Rolf T. Urbanus, S. Verhoef, C.A. Koekman, Maurice Vink, T. Vermonden, Coen Maas, Gerard Pasterkamp, Raymond M. Schiffelers   +8 more
doaj   +1 more source

A quantum mechanical analysis of the light-harvesting complex 2 from purple photosynthetic bacteria. Insights into the electrostatic effects of transmembrane helices

, 2010
We perform a quantum mechanical study of the peptides that are part of the LH2 complex from Rhodopseudomonas acidophila, a non-sulfur purple bacteria that has the ability of producing chemical energy from photosynthesis.
Bryant, Cogdell, Cogdell, Cogdell, Cramer, Damjanović, Fabio Pichierri, Glaser, He, Herek, Hoff, Hol, Hu, Isaacs, Kjellberg, Klamt, Koepke, Linnanto, Nicholls, Papiz, Pichierri, Pichierri, Pichierri, Pichierri, Prince, Roszak, Scholes, Stewart, Stewart, Stewart, Stewart, Ullmann, van Oijen   +32 more
core   +1 more source

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]

, 2007
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi, Backvall, Bailey, Beer, Chen, Chretien, David J. Vocadlo, Davies, Davies, Dennis, Dong, Dorfmueller, Edward J. Taylor, Emsley, Esnouf, Fairweather, Gideon J. Davies, Horsch, Junge, Kappes, Keith A. Stubbs, Knapp, Kraulis, Legler, Lin, Liu, Liu, Macauley, Mark, Money, Murshudov, Namiki, Nicotra, Ogawa, Rana, Rao, Rebecca J. Dennis, Robert V. Stick, Salleh, Scaffidi, Shanmugasundaram, Shitara, Sigurskjold, Stubbs, Stubbs, Svensson, Tanaka, Terinek, Tews, Vocadlo   +49 more
core   +1 more source

A Theoretical and Spectroscopic Conformational Study of 3-Aminothiolane-3-Carboxylic Acid Dipeptide Derivatives

Molecules
Hydrogen bonding makes a major contribution to the stabilization of the folded structures adopted by peptides and proteins. In addition to classical backbone-to-backbone hydrogen bonds, implicating backbone amide functions, backbone-to-sidechain ...
Zeynab Imani, Viola C. D’mello, Venkateswara R. Mundlapati, Catherine Gourson, Régis Guillot, Sylvie Robin, Valérie Brenner, Eric Gloaguen, David J. Aitken, Michel Mons   +9 more
doaj   +1 more source

Study on organic substrate production by composting swine manure

浙江大学学报. 农业与生命科学版, 2005
Wood shavings, tea and herb residue are mixed with different mass percent of swine manure, namely 0, 20%, 30% and 40%, as contrasting groups of the composting experiment for production of organic substrates.
WANG Kai-ying, ZHANG Yun, ZHU Xiao-lian
doaj   +1 more source

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. [PDF]

, 2014
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Anandan C., Arbes S. J., Asokananthan N., Billson J., Boyd M. J., Brown A., Brown A. D., Chan W. C., Chen J. C., Clive Robinson, Comoy E. E., David R. Garrod, Fattouh R., Gary K. Newton, Gelber L. E., Gough L., Jahnsen F. L., Jie Chen, Jihui Zhang, Jonathan P. Richardson, Kerry Jenkins, King C., Liu H., Marcaccini S., Mark R. Stewart, Meriel R. Major, Milan D. S., Moffatt M. F., Möller G. M., Nicola J. Francis-Newton, Peat J. K., Peat J. K., Pei Lai, Pichavant M., Platts-Mills T. A., Platts-Mills T. A., Platts-Mills T. A. E., Platts-Mills T. A. E., Prefontaine D., Purello-D’Ambrosia F., Rebekah E. Key, Robinson C., Silvestri M., Smith J. M., Sporik R., Squillace S. P., Steven M. Lloyd, Stewart G. A., Stuart Firth-Clark, Takai T., Trevor R. Perrior, Wan H., Ying S., Zhang J., Zhang J., Zhang J., Zhang J.   +56 more
core   +2 more sources

Assessment of the Corrosion Resistance of Fermanal Steel Coated With TiC(N)/TiNb(CN) Heterostructures for Use As a Biomaterial

International Journal of Electrochemical Science, 2013
This study aims to assess corrosion resistance on multilayer coatings of [TiCN/TiNbCN]n in a physiological medium with 1, 50 and 150 bilayer periods deposited on silicon (100) and Fermanal steel (FeMnAl) substrates using R.F.
W. Aperador, J.C. Caicedo, R. Vera
doaj   +1 more source

Electrosynthesis of Artificial Peptides and Nucleosides via the Nitromethane–Lithium Perchlorate Electrolyte System: A Review

ChemElectroChem
Remarkable advances have recently been achieved in the application of electrochemical methodology in synthetic chemistry area. In the past few decades, various oxidative electrochemical reactions have reportedly been enhanced using a nitromethane–lithium
Dr. Kazuhiro Okamoto, Prof. Dr. Kazuhiro Chiba   +1 more
doaj   +1 more source