Results 71 to 80 of about 648,030 (307)

A head-to-head comparison of conjugation methods for VHHs: Random maleimide-thiol coupling versus controlled click chemistry

open access: yesInternational Journal of Pharmaceutics: X, 2019
Targeted delivery of therapeutics is an attractive strategy for vascular diseases. Recently, variable domains of heavy-chain-only antibodies (VHHs) have gained momentum as targeting ligands to achieve this.
Marc V.A. van Moorsel   +8 more
doaj   +1 more source

A quantum mechanical analysis of the light-harvesting complex 2 from purple photosynthetic bacteria. Insights into the electrostatic effects of transmembrane helices

open access: yes, 2010
We perform a quantum mechanical study of the peptides that are part of the LH2 complex from Rhodopseudomonas acidophila, a non-sulfur purple bacteria that has the ability of producing chemical energy from photosynthesis.
Bryant   +32 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Study on organic substrate production by composting swine manure

open access: yes浙江大学学报. 农业与生命科学版, 2005
Wood shavings, tea and herb residue are mixed with different mass percent of swine manure, namely 0, 20%, 30% and 40%, as contrasting groups of the composting experiment for production of organic substrates.
WANG Kai-ying, ZHANG Yun, ZHU Xiao-lian
doaj   +1 more source

Processing waste printed circuit boards for material recovery [PDF]

open access: yes, 2007
PURPOSE We have investigated the use of pyrolysis for the processing of waste printed circuit boards (PCBs). The aim was to make the process of separating the organic, metallic, and glass fibre fractions of PCBs much easier and therefore make ...
Hall, W.J., Williams, P.T
core   +1 more source

Protein kinase FAM20C—when subcellular localization matters

open access: yesFEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Hydrocracking of atmospheric distillable residue of Mongolian oil

open access: yesMongolian Journal of Chemistry, 2014
Many catalytic processes to refine heavy part of crude oil have attracted much interest due to declining reserves of light crude oils. This study focused on hydrocracking process of atmospheric distillable residue of Mongolian crude oil in the first time
Ts Tugsuu   +3 more
doaj   +1 more source

Synthesis of Nitroxide-Annulated Carbocycles and Heterocycles [PDF]

open access: yes, 2012
New, pyrroline nitroxide annulated lactones, polycycles, and maleimide were synthesized by classical and microwave-assisted methodology. We report the application of the metathesis reaction in the presence of nitroxide yielding a pyrroline nitroxide ...
Berente, Zoltán   +4 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]

open access: yes, 2014
The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D.   +3 more
core   +1 more source

Home - About - Disclaimer - Privacy