Results 51 to 60 of about 1,771,943 (352)

Enhancing the Fit through Adaptive Co-management: Creating and Maintaining Bridging Functions for Matching Scales in the Kristianstads Vattenrike Biosphere Reserve, Sweden

open access: yesEcology and Society, 2007
In this article, we focus on adaptive governance of social-ecological systems (SES) and, more specifically, on social factors that can enhance the fit between governance systems and ecosystems. The challenge lies in matching multilevel governance system,
Per Olsson   +4 more
doaj   +1 more source

Resilient connections

open access: yesVITRUVIO - International Journal of Architectural Technology and Sustainability, 2021
The paper presents Axis Strutture, patented by the authors, awarded with V:alere funds (VAnvitelli pER la ricErca 2020) for the establishment of an innovative start-up, now academic spin-off. It is based on the assemble of iron and wood with 'pins' (in Latin 'axis') threaded to ensure an economic profit in line with the Sustainable Development Goals ...
Rossi, Adriana, Sara Gonizzi Barsanti
openaire   +6 more sources

Towards the resilient region?: policy activism and peripheral region development [PDF]

open access: yes, 2010
Discussions of local and regional development have recently broadened from a preoccupation with growth to one which captures the notion of resilience. This paper makes two main contributions to these debates. First, the paper critiques static equilibrium-
Dawley, Stuart   +2 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The problem of spatial fit in social-ecological systems: detecting mismatches between ecological connectivity and land management in an urban region

open access: yesEcology and Society, 2014
The problem of institutional fit in social-ecological systems has been empirically documented and conceptually discussed for decades, yet there is a shortage of approaches to systematically and quantitatively examine the level of fit. We address this gap,
Arvid Bergsten   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Photovoice for mobilizing insights on human well-being in complex social-ecological systems: case studies from Kenya and South Africa

open access: yesEcology and Society, 2018
The value of diverse perspectives in social-ecological systems research and transdisciplinarity is well recognized. Human well-being and how it is derived from dynamic ecosystems is one area where local knowledge and perspectives are critical for ...
Vanessa A. Masterson   +2 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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