Results 31 to 40 of about 77,222 (268)

Surface discharge imaging in presence of deposited space charges in non‐uniform DC electric field

High Voltage, 2021
An investigation is made of the influence of an accumulated charge sprinkled on the surface of an epoxy resin plate in corona mode on partial discharge inception and its forms as analyzed by optical imaging at DC voltage. The effects of the polarities of
Marek Florkowski, Dariusz Krześniak, Maciej Kuniewski, Paweł Zydroń   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis

Beilstein Journal of Organic Chemistry, 2012
Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated ...
Jian Yin, Steffen Eller, Mayeul Collot, Peter H. Seeberger   +3 more
doaj   +1 more source

Le moulage pour la reconstitution des lacunes en restauration de la céramique et du verre

CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2012
The technique of gap-filling by molding is very vast. It presents a wide range of products and processes than can be used in the field of the restoration of ceramic and glass objects.
Hélène Blanpain
doaj   +1 more source

Partial discharge characteristics of an air gap defect in the epoxy resin of a saturable reactor under an exponential decay pulse voltage

High Voltage, 2020
Saturable reactor insulation is currently stressed by an exponential decay pulse voltage under normal operating conditions. The partial discharge (PD) characteristics of epoxy resin under an exponential decay pulse voltage were studied here and were ...
Lu Gui, Yan Mi, Shengchu Deng, Lulu Liu, Xin Ge, Wenmin Ouyang   +5 more
doaj   +1 more source

In‐situ observation of electrical tree evolution in epoxy dielectrics with internal cracks

High Voltage, 2021
Gas‐filled internal crack might appear in thermoset materials like epoxy resin during the equipment manufacturing, which would become a vulnerable local region to initiate the electrical tree, thus prone to cause insulation failure. The withstand voltage
Zehua Wu, Huidong Tian, Sijia Zhu, He Li, Qingyu Wang, Zongliang Xie, Peng Liu, Zongren Peng   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source