Results 41 to 50 of about 123,760 (314)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Le moulage pour la reconstitution des lacunes en restauration de la céramique et du verre

open access: yesCeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2012
The technique of gap-filling by molding is very vast. It presents a wide range of products and processes than can be used in the field of the restoration of ceramic and glass objects.
Hélène Blanpain
doaj   +1 more source

Characterization of mechanical and bonding properties of anchoring resins under elevated temperature [PDF]

open access: yes, 2023
Resin anchored rock bolts are widely used in the construction and mining industries to support and reinforce underground roadways and openings. However, increasing the depth of underground openings, particularly in coal mines, has presented a challenge ...
Motallebiyan, Amin   +17 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis

open access: yesBeilstein Journal of Organic Chemistry, 2012
Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated ...
Jian Yin   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

HYPERBRANCHED ALKYD RESINS OBTAINED FROM A HYPERBRANCHED POLYESTER POLYOL OF THE FIFTH GENERATION AND TALL OIL FATTY ACID

open access: yes, 2023
The first aim of this study was to synthesize hyperbranched alkyd resins from tall oil fatty acids and a hyperbranched polyester polyol via an esterification reaction.
Murillo Ruiz, Edwin Alberto   +2 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The role of expansion angle and speed on shish-kebab formation in expansion pipe extruder head explored by high temperature rapid stretch

open access: yesPolymer Testing, 2021
Morphology and microstructures play a significant role on properties of polymer products. Self-reinforced shish-kebab formed inside the products by elongational flow induced orientation can improve the tensile strength and pressure rating properties, and
Yuxi Pan   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

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