Results 61 to 70 of about 8,162,878 (359)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Modified genome comparison method: a new approach for identification of specific targets in molecular diagnostic tests using Mycobacterium tuberculosis complex as an example

BMC Infectious Diseases, 2018
Background The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve this goal. In this study, we aimed
Alireza Neshani, Reza Kamali Kakhki, Mojtaba Sankian, Hosna Zare, Amin Hooshyar Chichaklu, Mahsa Sayyadi, Kiarash Ghazvini   +6 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Use of a national repository of Fourier-transform infrared spectroscopy spectra enables fast detection of silent outbreaks and prevention of spread of new antibiotic-resistant sequence types

Antimicrobial Resistance and Infection Control
Background The reference microbiology laboratory of Israel’s National Institute for Antibiotic Resistance and Infection Control has established a national repository of isolates analyzed by Fourier-transform infrared (FTIR) spectroscopy and their spectra.
Mor N. Lurie-Weinberger, Elizabeth Temkin, Ophir Kastel, Moshe Bechor, Darya Bychenko-Banyas, Reut Efrati-Epchtien, Gabrielle D. Levi, Nadya Rakovitsky, Alona Keren-Paz, Yehuda Carmeli, The Antimicrobial Resistance Surveillance Group   +10 more
doaj   +1 more source

Interstrip resistance measurement. [PDF]

, 2009
In ATLAS SCT community two methods of interstrip resistance measurements are used: a) measuring the resistance between two strips and comparing it with a separately measured strip-to bias-rail resistance and b) applying DC voltage to one strip and ...
Chilingarov, Alexandre
core  

International governance and local resistance in Kosovo: The thin line between ethical, emancipatory and exclusionary politics [PDF]

, 2011
This paper examines the emergence and implications of local resistance against the practice of liberal peace-building in post-conflict Kosovo, as pursued by the international community and local authorities.
Visoka, Gëzim
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Quantitative trait loci mapping for resistance to maize streak virus in F2: 3 population of tropical maize [PDF]

, 2020
Open Access Article; Published online: 01 Feb 2020Maize streak virus (MSV) continues to be a major biotic constraint for maize production throughout Africa.
Azuh, V., Garcia-Oliveira, A.L., Gedil, M., Jacob, O.O., Kumar, P.L., Menkir, A.   +5 more
core   +2 more sources

Is resistant hypertension really resistant? [PDF]

American Journal of Hypertension, 2001
Managing resistant hypertension is difficult and mostly involves expensive testing seeking an underlying secondary cause. This study was undertaken to determine 1) the extent of the white-coat phenomenon in patients with resistant hypertension, and 2) whether 24-h ambulatory blood pressure (BP) monitoring (ABPM) or having BP recorded by a nurse instead
Megan L. Buddle, Allison Martin, Mark Brown   +2 more
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source