Results 81 to 90 of about 8,162,878 (359)
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Scientific Reports, 2017 Recent metagenomic studies suggest that innate and adaptive immune phenotypes can be programmed via gut microbiota-host interactions mediated via activation of pattern recognition receptors (PRRs) on host cells.
Yi Xiao +9 more
doaj +1 more source
BMC Medical Research Methodology, 2019 Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either new infection or recrudescence.
Prabin Dahal +5 more
doaj +1 more source
BMC Infectious Diseases, 2020 Background Fluoroquinolones are broad-spectrum antibiotics that are recommended, and increasingly important, for the treatment of multidrug-resistant tuberculosis (MDR-TB). Resistance to fluoroquinolones is caused by mutations in the Quinolone Resistance
Mahdieh Sayadi +7 more
doaj +1 more source
The Burden of antimicrobial Resistance in the americas in 2019: a Cross-Country Systematic analysis [PDF]
, 2023 BACKGROUND: Antimicrobial resistance (AMR) is an urgent global health challenge and a critical threat to modern health care. Quantifying its burden in the WHO Region of the Americas has been elusive-despite the region\u27s long history of resistance ...
Antimicrobial Resistance Collaborators
core +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Identification of molecular markers associated to new sources of resistance to the root-knot nematode in cotton : S02T04 [PDF]
, 2013 The root-knot nematode (RKN) Meloidogyne incognita is a major constraint in cotton (Gossypium hirsutum L.) production in numerous countries. Control of RKN has been hampered by the lack of options for crop rotation and even more, by the lack of high ...
Barroso, Paulo Augusto Vianna +4 more
core
Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma. [PDF]
, 2017 The advent of genomics has led to the identification of specific "driver" mutations in oncogenic kinases, and the development of targeted small molecule inhibitors to block their tumor-driving functions.
Bivona, Trever G, Neel, Dana S
core +1 more source
Nature Ecology & Evolution, 2019 A game theory study supported by in vitro experimental data shows that drug treatment of non-small-cell lung cancer cells causes the cells to switch between evolutionary games they play among each other. Moreover, the work calls into question standard assumptions on the fitness costs of drug resistance to cancer cells.
openaire +3 more sources
Learning to Resist and Resisting Learning
Social Sciences, 2022 The COVID crisis has disrupted routine patterns and practices across all spheres of everyday life, rupturing social relations and destabilising our capacity for building coherent selves and communities by recollecting the past and imagining potential futures.
openaire +2 more sources