Results 71 to 80 of about 3,385,258 (303)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Oxygen consumption during concurrent training: influence of intra-session exercise sequence and aerobic exercise modality

Biology of Sport, 2018
To compare the acute effects of different intra-session exercise sequences and aerobic exercise modalities during concurrent training sessions on oxygen consumption (VO 2 ) and energy expenditure (EE) in young women.
Rodrigo Ferrari, Cristine Alberton, Stephanie Pinto, Eduardo Cadore, Ronei Pinto, Luiz Fernando Kruel   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Research progress on the rehabilitation effects of different intensity resistance training on patients with cardiovascular diseases

Huli yanjiu, 2019
Exercise rehabilitation played a vital role in the prevention and treatment of cardiovascular diseases.As the core element of exercise rehabilitation,exercise intensity was closely related to the effectiveness and safety of patients′ sports ...
张爽, 陈影, 余珍, 潘利妞, 杨东斌, 杨阳, 张伟宏   +6 more
doaj  

The efficacy of early progressive resistance exercise in the postoperative management of pancreaticoduodenectomy for pancreatic cancer: a randomized controlled trial

Frontiers in Surgery
BackgroundEnhanced Recovery After Surgery (ERAS) is of significant importance to the prognosis of patients with pancreatic cancer who have undergone pancreaticoduodenectomy. This study aims to analyze the efficacy of early progressive resistance exercise
Xuexue Liu, Neng Shi, Rui Li, Yuan Song
doaj   +1 more source

Effects of weight-lifting or resistance exercise on breast cancer-related lymphedema: A systematic review

International Journal of Nursing Sciences, 2019
The purpose of this systematic review was to identify the effects of weight-lifting or resistance exercise on breast cancer-related lymphedema. Published articles written in English were retrieved from electronic databases, including ScienceDirect ...
Ausanee Wanchai, Jane M. Armer
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise

, 2012
LUNDBERG, T. R., R. FERNANDEZ-GONZALO, T. GUSTAFSSON, and P. A. TESCH. Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise. Med. Sci. Sports Exerc., Vol. 44, No. 9, pp. 1680-1688, 2012.
Fernandez-Gonzalo, Rodrigo,, Gustafsson, Thomas,, Tesch, Per A.,, Lundberg, Tommy R.,   +3 more
core   +1 more source

Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training

Experimental Physiology
Exercise‐induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance or resistance exercise in vivo or ...
Annabelle Fowler, Katherine R. Knaus, Stephanie Khuu, Ali Khalilimeybodi, Simon Schenk, Samuel R. Ward, Andrew C. Fry, Padmini Rangamani, Andrew D. McCulloch   +8 more
doaj   +1 more source