Results 81 to 90 of about 3,385,258 (303)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men [PDF]

, 2004
Objectives: We investigated whether a session of prior exercise could ameliorate postprandial endothelial dysfunction. Background: Endothelial function is impaired after fat ingestion, and this may be related to rises in triglyceride concentrations.
John R. Petrie, Stephen J. Cleland, Petrie, J.R., Sattar, N., William R. Ferrell, Cleland, Stephen J., Caslake, Muriel J., Gill, Jason M.R., Jason M.R. Gill, Muriel J. Caslake, Packard, C.J., Petrie, John, Ali Al-Mamari, Sattar, Naveed, Gill, J.M.R., Ferrell, William R., Petrie, John R., Al-Mamari, A., Caslake, M.J., Naveed Sattar, Cleland, S.J., Chris J. Packard, Ferrell, W.R., Al-Mamari, Ali, Packard, Chris J.   +24 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Effects of intrinsic aerobic capacity on an isometric forelimb resistance exercise task and bulbar motor function in aging rats

Brain Research Bulletin
The beneficial effects of aerobic exercise in aging are well established but can be limited by low aerobic capacity. Resistance exercise is also beneficial, yet little is known about how intrinsic aerobic capacity influences resistance exercise ...
Emma D. Renwick, Kimberly G. Stanford, Julia Stopperan, Emily Fey, Ava K. Lee, Colin S. McCoin, Lauren G. Koch, Steve L. Britton, Fengyan Deng, Jonathan W. Pinkston, Paige C. Geiger, John P. Thyfault, John A. Stanford   +12 more
doaj   +1 more source

The Feasibility of performing resistance exercise with acutely ill hospitalized older adults

BMC Geriatrics, 2003
Background For older adults, hospitalization frequently results in deterioration of mobility and function. Nevertheless, there are little data about how older adults exercise in the hospital and definitive studies are not yet available to determine what ...
Rockwood Kenneth, Earl Marie E, Hubley-Kozey Cheryl L, MacDonald Elizabeth A, Mallery Laurie H, MacKnight Chris   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source