Results 101 to 110 of about 8,603,806 (347)

Gene amplification and insecticide resistance

Pest Management Science, 2011
AbstractPesticide resistance in arthropods has been shown to evolve by two main mechanisms, the enhanced production of metabolic enzymes, which bind to and/or detoxify the pesticide, and mutation of the target protein, which makes it less sensitive to the pesticide.
Bass, C., Field, L. M.
openaire   +2 more sources

PRGdb 3.0: a comprehensive platform for prediction and analysis of plant disease resistance genes

Nucleic Acids Res., 2017
The Plant Resistance Genes database (PRGdb; http://prgdb.org) has been redesigned with a new user interface, new sections, new tools and new data for genetic improvement, allowing easy access not only to the plant science research community but also to ...
C. M. Osuna-Cruz, Andreu Paytuví Gallart, A. Donato, Vicky Sundesha, G. Andolfo, R. A. Cigliano, W. Sanseverino, M. Ercolano   +7 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Distribution of Arsenic Resistance Genes in Prokaryotes

Frontiers in Microbiology, 2018
Arsenic is a metalloid that occurs naturally in aquatic and terrestrial environments. The high toxicity of arsenic derivatives converts this element in a serious problem of public health worldwide.
Ibtissem Ben Fekih, Chengkang Zhang, Y. Li, Yi Zhao, H. Alwathnani, Q. Saquib, C. Rensing, C. Cervantes   +7 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PRGminer: harnessing deep learning for the prediction of resistance genes involved in plant defense mechanisms

Frontiers in Plant Science
Plant resistance genes are crucial in plant defense systems against a variety of diseases and pests. These plant-specific genes encode proteins that identify particular molecular patterns associated with pathogens invading the plants.
Naveen Duhan, Naveen Duhan, Rakesh Kaundal, Rakesh Kaundal   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Transcriptomics and metabolomics analyses provide insights into resistance genes of tree ferns

Frontiers in Genetics
As ancient organisms, tree ferns play a crucial role as an evolutionary bridge between lower and higher plant species, providing various utilitarian benefits.
Weicheng Yang, Qinqin He, Lijun Zhang, Jiaxing Xiao, Jiao Yang, Bingjie Che, BingChen Zhang, Handan Chen, Jiang Li, Yu Jiang   +9 more
doaj   +1 more source

Genetic Basis and Clonal Population Structure of Antibiotic Resistance in Campylobacter jejuni Isolated From Broiler Carcasses in Belgium

Frontiers in Microbiology, 2018
Human campylobacteriosis is the leading food-borne zoonosis in industrialized countries. This study characterized the clonal population structure, antimicrobial resistance profiles and occurrence of antimicrobial resistance determinants of a set of ...
Mohamed Elhadidy, Mohamed Elhadidy, William G. Miller, Hector Arguello, Avelino Álvarez-Ordóñez, Alexandra Duarte, Alexandra Duarte, Katelijne Dierick, Nadine Botteldoorn   +8 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source