Results 71 to 80 of about 1,535,251 (311)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

THE SOUTH AFRICAN ‘WAR RESISTANCE’ MOVEMENT 1974–1994

Scientia Militaria, 2015
From the mid-1970s until the onset of negotiations to end apartheid in 1990, escalating military conflict in the Southern African region was accompanied by a steady increase of conscription dependent on the white male population in South Africa. This was
Gavin Cawthra
doaj   +1 more source

A Comparative Study of Reflections of Resistance in the Poetry of Malek-o-Shoara Bahar and Amal Donqol [PDF]

ادبیات تطبیقی, 2017
Resistance literature is usually created in the conditions of oppression, inner despotism, lack of social and individual freedom, defiance of law, and foreign aggression.
Ebrahim Vasheghani Farahani, رضا تواضعی   +1 more
doaj   +1 more source

\u3cem\u3eArabidopsis\u3c/em\u3e AZI1 Family Proteins Mediate Signal Mobilization for Systemic Defence Priming [PDF]

, 2015
Priming is a major mechanism behind the immunological \u27memory\u27 observed during two key plant systemic defences: systemic acquired resistance (SAR) and induced systemic resistance (ISR).
Cecchini, Nicolas M., Gifford, Andrew N., Greenberg, Jean T., Schläppi, Michael, Steffes, Kevin   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Comparative analysis of biomechanical characteristics between the new Tai Chi elastic band exercise for opening and closing movement and elastic band resistance training for the reverse fly movement [PDF]

PeerJ
Background The objective of this study was to compare and analyze the representative opening and closing movement of Tai Chi elastic band exercise with the reverse fly movement of elastic band resistance training. The aim was to explore the biomechanical
Mingyu Liu, Cuihan Li, Xiongfeng Li, Jianwei Zhang, Haojie Li, Yameng Li, Qiuyang Wei, Zaihao Chen, Jiahao Fu, Yanying Li, Meize Cui, Lujia Li, Peng Zhang, Yuerong Huang, Yuxin Ma, Jianan Xu, Shaojun Lyu, Yunchao Ma   +17 more
doaj   +2 more sources

Analysis of the potential mechanisms of rockbursts [PDF]

, 2006
Sudden slip on geological faults or other discontinuities in rock may be preceded by an initial phase of "slow" fault creep. A simple plane strain model of a suddenly loaded fault is analysed to illustrate the possible transition from stable slip ...
Napier, J.A.L.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Microwave photoresistance in a two-dimensional electron gas with separated Landau levels

, 2011
Theories of microwave-induced resistance oscillations in high-mobility two-dimensional electron gas predict that with decreasing oscillation order $n$ or with increasing frequency $\omega$ the photoresistance maxima should appear closer to the cyclotron ...
Hatke, A. T., Pfeiffer, L. N., West, K. W., Zudov, M. A.   +3 more
core   +1 more source