The role of hormonal and nutritional biomarkers in predicting immune checkpoint inhibitor efficacy: current limitations and future prospects. [PDF]
Front ImmunolYuan R, Lan Y, Wu M, Lu X.
europepmc +1 more source
A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy
Clinical Genetics, EarlyView.PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady +3 more
wiley +1 more source
Bibliometric analysis of trends and hotspots in thyroid hormone research in patients with bipolar disorder (1998-2022): Bibliometric review. [PDF]
Medicine (Baltimore)Song X, Yi L, Wang S, Wang L.
europepmc +1 more source
Liver Organoids: From Disease Modelling to Regenerative Medicine
Cell Proliferation, EarlyView.Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang +5 more
wiley +1 more source
Low Preoperative Free Triiodothyronine, Particularly in Females, Is Associated With Reduced Weight Loss and Diabetes Remission After Bariatric Surgery in Euthyroid Adults. [PDF]
Diabetes Metab Res RevLi S +8 more
europepmc +1 more source
Diabetic Medicine, EarlyView.Abstract Introduction Older adults with diabetes have an increased risk of falls due to neuropathy, impaired bone health and cardiovascular disease, resulting in significant morbidity and mortality. Conventional fall‐prevention programmes primarily target strength and balance, while cognitive‐motor integration, essential for safe mobility in complex ...
Aksayan Arunanthy Mahalingasivam +4 more
wiley +1 more source
Thyroid hormone sensitivity and insulin resistance in euthyroid adults in Beijing: A cross-sectional study. [PDF]
Medicine (Baltimore)Zhang M +5 more
europepmc +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Neuroendocrine-immune perturbations in metabolic disease: pathophysiological mechanisms underlying cognitive impairment. [PDF]
Front Hum NeurosciFraer A +4 more
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Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells
The FEBS Journal, EarlyView.MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe +5 more
wiley +1 more source