Results 41 to 50 of about 485,715 (313)

Antibiotics: Combatting Tolerance To Stop Resistance

mBio, 2019
Antibiotic resistance poses an alarming and ever-increasing threat to modern health care. Although the current antibiotic crisis is widely acknowledged, actions taken so far have proved insufficient to slow down the rampant spread of resistant pathogens.
Windels, Etthel, Michiels, Joran, Van den Bergh, Bram, Fauvart, maarten, Michiels, jan   +4 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparison Between Core Set Selection Methods Using Different Illumina Marker Platforms: A Case Study of Assessment of Diversity in Wheat

Frontiers in Plant Science, 2020
Collections of plant genetic resources stored in genebanks are an important source of genetic diversity for improvement in plant breeding programs and for conservation of natural variation.
Behnaz Soleimani, Heike Lehnert, Jens Keilwagen, Joerg Plieske, Frank Ordon, Sara Naseri Rad, Martin Ganal, Sebastian Beier, Dragan Perovic   +8 more
doaj   +1 more source

A Genome-Wide Association Study Pinpoints Quantitative Trait Genes for Plant Height, Heading Date, Grain Quality, and Yield in Rye (Secale cereale L.)

Frontiers in Plant Science, 2021
Rye is the only cross-pollinating Triticeae crop species. Knowledge of rye genes controlling complex-inherited traits is scarce, which, currently, largely disables the genomics assisted introgression of untapped genetic variation from self-incompatible ...
Dörthe Siekmann, Dörthe Siekmann, Gisela Jansen, Anne Zaar, Andrzej Kilian, Franz Joachim Fromme, Bernd Hackauf   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fluorescence-based CAPS Multiplex Genotyping on Capillary Electrophoresis Systems

Bio-Protocol, 2015
Recent advances in next-generation sequencing techniques allow the detection of a large number of SNPs and their use in a high throughput manner. However, Cleaved Amplified Polymorphic Sequences (CAPSs) still play a significant role as complement to ...
Jelena Perovic, Cristina Silvar, Dragan Perovic, Nils Stein, Frank Ordon   +4 more
doaj   +1 more source

Dissection of a grain yield QTL from wild emmer wheat reveals sub-intervals associated with culm length and kernel number

Frontiers in Genetics, 2022
Genetic diversity in wheat has been depleted due to domestication and modern breeding. Wild relatives are a valuable source for improving drought tolerance in domesticated wheat.
Mathieu Deblieck, Gergely Szilagyi, Fatiukha Andrii, Yehoshua Saranga, Madita Lauterberg, Kerstin Neumann, Tamar Krugman, Dragan Perovic, Klaus Pillen, Frank Ordon   +9 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Huanglongbing Resistance and Tolerance in Citrus [PDF]

Journal of Citrus Pathology, 2014
Huanglongbing (HLB) is severely impacting Florida citrus. Productivity declines in many HLB-affected genotypes, often with greatly thinned canopies. Fruit size and quality are often adversely affected as the disease advances. HLB was assessed in diverse cultivars in commercial groves with high HLB-incidence.
Stover, E., McCollum, G., Driggers, R., Duan, Y., Shatters, Jr., R., Ritenour, M., Hall, D. G., Chaparro, J.   +7 more
openaire   +3 more sources

Association genetics studies on frost tolerance in wheat (Triticum aestivum L.) reveal new highly conserved amino acid substitutions in CBF-A3, CBF-A15, VRN3 and PPD1 genes

BMC Genomics, 2018
Background Understanding the genetic basis of frost tolerance (FT) in wheat (Triticum aestivum L.) is essential for preventing yield losses caused by frost due to cellular damage, dehydration and reduced metabolism.
Steve Babben, Edgar Schliephake, Philipp Janitza, Thomas Berner, Jens Keilwagen, Michael Koch, Fernando Alberto Arana-Ceballos, Sven Eduard Templer, Yuriy Chesnokov, Tatyana Pshenichnikova, Jörg Schondelmaier, Andreas Börner, Klaus Pillen, Frank Ordon, Dragan Perovic   +14 more
doaj   +1 more source