Results 51 to 60 of about 485,715 (313)

Long-Amplicon Single-Molecule Sequencing Reveals Novel, Trait-Associated Variants of VERNALIZATION1 Homoeologs in Hexaploid Wheat

Frontiers in Plant Science, 2022
The gene VERNALIZATION1 (VRN1) is a key controller of vernalization requirement in wheat. The genome of hexaploid wheat (Triticum aestivum) harbors three homoeologous VRN1 loci on chromosomes 5A, 5B, and 5D.
Manar Makhoul, Harmeet S. Chawla, Harmeet S. Chawla, Benjamin Wittkop, Andreas Stahl, Kai Peter Voss-Fels, Holger Zetzsche, Rod J. Snowdon, Christian Obermeier   +8 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Helminths and immunological tolerance [PDF]

, 2014
Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection.
McSorley, Henry J., Maizels, Rick M., Maizels, Rick M, Johnston, Chris J C, Wigmore, Stephen J, Johnston, Chris J.C., Wigmore, Stephen J., Anderton, Stephen M, McSorley, Henry J, Anderton, Stephen M., Johnston, Chris J. C., McSorley, Henry J.; id_orcid   +11 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Endotoxin Induced Resistance to Infections and Tolerance

Experimental Biology and Medicine, 1963
SummaryThe ability of endotoxin to increase the resistance of animals to infection is maintained or increased after repeated administration of endotoxin. This finding contrasts with the development of tolerance to the other effects of endotoxin, such as the diminution or disappearance of the lethal and granulopenic effect of endotoxin on repeated ...
F M, BERGER, G M, FUKUI
openaire   +2 more sources

Genome wide association study of frost tolerance in wheat

Scientific Reports, 2022
Winter wheat growing areas in the Northern hemisphere are regularly exposed to heavy frost. Due to the negative impact on yield, the identification of genetic factors controlling frost tolerance (FroT) and development of tools for breeding is of prime ...
Behnaz Soleimani, Heike Lehnert, Steve Babben, Jens Keilwagen, Michael Koch, Fernando Alberto Arana-Ceballos, Yuriy Chesnokov, Tatyana Pshenichnikova, Jörg Schondelmaier, Frank Ordon, Andreas Börner, Dragan Perovic   +11 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Tolerance: the forgotten child of plant resistance

PeerJ, 2017
Plant resistance against insect herbivory has greatly focused on antibiosis, whereby the plant has a deleterious effect on the herbivore, and antixenosis, whereby the plant is able to direct the herbivore away from it. Although these two types of resistance may reduce injury and yield loss, they can produce selection pressures on insect herbivores that
Peterson, Robert K, Varella, Andrea C, Higley, Leon G   +2 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

PEG treatment is unsuitable to study root related traits as it alters root anatomy in barley (Hordeum vulgare L.)

BMC Plant Biology
Background The frequency and severity of abiotic stress events, especially drought, are increasing due to climate change. The plant root is the most important organ for water uptake and the first to be affected by water limitation.
Veronic Töpfer, Michael Melzer, Rod J. Snowdon, Andreas Stahl, Andrea Matros, Gwendolin Wehner   +5 more
doaj   +1 more source