Results 11 to 20 of about 3,559,343 (361)

Resistance-resistant antibiotics [PDF]

Trends in Pharmacological Sciences, 2014
New antibiotics are needed because drug resistance is increasing while the introduction of new antibiotics is decreasing. We discuss here six possible approaches to develop 'resistance-resistant' antibiotics. First, multitarget inhibitors in which a single compound inhibits more than one target may be easier to develop than conventional combination ...
Eric, Oldfield, Xinxin, Feng
openaire   +2 more sources

Olaparib for Metastatic Castration-Resistant Prostate Cancer.

New England Journal of Medicine, 2020
BACKGROUND Multiple loss-of-function alterations in genes that are involved in DNA repair, including homologous recombination repair, are associated with response to poly(adenosine diphosphate-ribose) polymerase (PARP) inhibition in patients with ...
J. D. de Bono, J. Mateo, K. Fizazi, F. Saad, N. Shore, S. Sandhu, K. Chi, O. Sartor, N. Agarwal, D. Olmos, A. Thiery-Vuillemin, P. Twardowski, N. Mehra, C. Goessl, Jinyu Kang, J. Burgents, Wenting Wu, A. Kohlmann, C. Adelman, M. Hussain   +19 more
semanticscholar   +1 more source

European Society of clinical microbiology and infectious diseases (ESCMID) guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli (endorsed by ESICM -European Society of intensive care Medicine).

Clinical Microbiology and Infection, 2021
SCOPE These ESCMID guidelines address the targeted antibiotic treatment of 3rd generation cephalosporin-resistant Enterobacterales (3GCephRE) and carbapenem-resistant Gram-negative bacteria, focusing on the effectiveness of individual antibiotics and on ...
M. Paul, E. Carrara, P. Retamar, T. Tängdén, R. Bitterman, R. Bonomo, J. D. De Waele, G. Daikos, M. Akova, S. Harbarth, C. Pulcini, J. Garnacho-Montero, K. Seme, M. Tumbarello, P. Lindemann, Sumanth Gandra, Yunsong Yu, M. Bassetti, J. Mouton, E. Tacconelli, J. R. Baño   +20 more
semanticscholar   +1 more source

Multidrug-resistant tuberculosis. [PDF]

, 2008
BACKGROUND: With almost 9 million new cases each year, tuberculosis remains one of the most feared diseases on the planet. Led by the STOP-TB Partnership and WHO, recent efforts to combat the disease have made considerable progress in a number of ...
Zager, Ellen M, McNerney, Ruth
core   +1 more source

Effects of dietary lysine levels on growth performance, nutrient digestibility, serum metabolites, and carcase and meat quality of Yacha pigs

Italian Journal of Animal Science, 2022
The objective was to evaluate the effect of different standardised ileal digestible lysine (SID-Lys) levels on performance, nutrient digestibility, serum metabolites, and carcase and meat traits of Yacha pigs.
Jiameng Yang, Bin Huo, Kun Wang, Xuecai Hu, Lijia Zhang, Hua Li, Lingjie Huang, Jiayong Tang, Jian Li, Yan Lin, Shengyu Xu, Lianqiang Che, Gang Tian, Bin Feng, De Wu, Zhengfeng Fang   +15 more
doaj   +1 more source

Prevalence and Diversity of Antibiotic Resistant Escherichia coli From Anthropogenic-Impacted Larut River

Frontiers in Public Health, 2022
Aquatic environments, under frequent anthropogenic pressure, could serve as reservoirs that provide an ideal condition for the acquisition and dissemination of antibiotic resistance genetic determinants.
Chui Wei Bong, Chui Wei Bong, Kyle Young Low, Kyle Young Low, Lay Ching Chai, Lay Ching Chai, Choon Weng Lee, Choon Weng Lee   +7 more
doaj   +1 more source

Resisting Resistance [PDF]

Annual Review of Cancer Biology, 2017
Targeted therapies, immunotherapies, and improved chemotherapies are being developed to reduce the suffering and mortality that come from human cancer. Although these approaches, and in particular combinations of them, are expected to succeed eventually to a large degree, they all suffer one obstacle: Populations of replicating cells move away ...
Ivana Bozic, Martin A. Nowak
openaire   +1 more source

Effect of Sweet Potato Vine on the Onset of Puberty and Follicle Development in Chinese Meishan Gilts

Animals, 2019
This study was conducted to evaluate the effects of sweet potato vine on the onset of puberty and the follicular development in the ovaries of Chinese Meishan gilts. A total of 20 Meishan gilts (initial body weight at 30 ± 0.18 kg) were randomly fed
Pan Zhang, Meng Cao, Jian Li, Yan Lin, Zhengfeng Fang, Lianqiang Che, Bin Feng, Yong Zhuo, Jianping Wang, De Wu, Shengyu Xu   +10 more
doaj   +1 more source

Resistance to “Castration-Resistant” [PDF]

The Oncologist, 2014
The author challenges the use of the phrase “castration resistance,” which is widely used in the literature and also appears in a recent article by Merseburger et al.
openaire   +2 more sources

Case Report: Transformation From Non-Small Cell Lung Cancer to Small Cell Lung Cancer During Anti-PD-1 Therapy: A Report of Two Cases

Frontiers in Oncology, 2021
BackgroundHistological transformation of lung cancer to small cell lung cancer (SCLC) is uncommon. It is a small subset of the possible resistance mechanisms, even in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer treated with
Qian Shen, Jingjing Qu, Lingyan Sheng, Qiqi Gao, Jianying Zhou   +4 more
doaj   +1 more source