Results 101 to 110 of about 32,295 (302)

Protocol for Cancloz: multicentre randomised, placebo-controlled, double-blind, parallel-group adaptive trial of cannabidiol for clozapine-resistant schizophrenia

BJPsych Open
Background Although clozapine is the most effective antipsychotic for people with treatment-resistant schizophrenia (TRS), only 40% of people with TRS respond, and there is limited evidence for augmentation agents.
Dan Siskind, Claudia Bull, Shuichi Suetani, Nicola Warren, Anastasia Suraev, Iain McGregor, Steve Kisely, Veronica De Monte, Mike Trott, Manju Shine, Vikas Moudgil, Gail Robinson, Stephen Parker, Ravikumar Krishnaiah, Terry Stedman, Allan Drummond, Sarah Medland, Ravi Iyer, Andrea Baker   +18 more
doaj   +1 more source

Increased interleukin-2 serum levels were associated with psychopathological symptoms and cognitive deficits in treatment-resistant schizophrenia

, 2015
Accumulating evidence showed that interleukin-2 (IL-2) may be involved in the pathophysiology of schizophrenia. Increased IL-2 levels have been found in the serum of schizophrenia patients with mixed results.
Zunta-Soares, Giovana B., Tan, Yunlong, Soares, Jair C., Tan, Shuping, Zhang, Xiang Yang, Cao, Bo, Yang, Fu-De, Li, Yanli, Wang, Zhiren   +8 more
core   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Disc 1 and neurogenesis in schizophrenia and other major psychiatric disorders : a post-mortem study of the human hippocampus [PDF]

, 2013
Psychiatric illnesses are disorders that affect millions worldwide. Evidence from quantitative and molecular genetics analysis suggests a strong genetic component to these disorders.
Oladimeji, Paul Babajide
core  

Genetic Studies in Treatment-Resistant Schizophrenia

, 2010
Treatment of patients with schizophrenia who fail to respond to adequate amounts of antipsychotics is a major challenge. The proportion of schizophrenia that is treatment-resistant has been estimated at 20–40%.
Vincenzo De Luca, Souza, Renan P, De Luca, Vincenzo, Herbert Y Meltzer, Panariello, Fabio, Meltzer, Herbert Y, Fabio Panariello, Renan P Souza   +7 more
core   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

The CIPP-TRS Corpus: Corpus Construction and Preliminary Analyses

LingBaW
Schizophrenia, a neurodevelopmental disorder, significantly affects cognitive and linguistic functions, often resulting in disorganized speech, reduced syntactic complexity, and impaired discourse cohesion.
Laura Tagliaferro, Ludovica Fiorentino, Raffaele Guarasci, Luigi Franzese, Viviana Maria Saia, Giancarlo Spennato, Felice Iasevoli, Roberto Vitelli, Andrea de Bartolomeis, Francesca M. Dovetto   +9 more
doaj   +1 more source

Mothering Through the Experiences of Homelessness With a Particular Focus on Child Separation in High‐Income Countries: A Scoping Review

Child &Family Social Work, EarlyView.
ABSTRACT Mothers who experience homelessness represent one of the most vulnerable and marginalized groups, often facing separation from their children as a consequence of housing instability and intersecting challenges. While there is a substantial body of research on parenting in the context of homelessness, little is known about the experience of ...
Olayinka Ariba, Abe Oudshoorn, Cheryl Forchuk, Nadine Wathen, Corinna Easton, Roxanne Isard   +5 more
wiley   +1 more source

Treatment resistance in schizophrenia [PDF]

British Journal of Psychiatry, 1993
S, Mirza, V S, Babu, E, Vithayathil
openaire   +2 more sources

Sulpiride augmentation for schizophrenia

, 2010
BackgroundSulpiride may be used in combination with other antipsychotic drugs in the hope of augmenting effectiveness - especially for those whose schizophrenia has proved resistant to treatment.Objectives To evaluate the effects of sulpiride ...
Wang, Jijun, Soares, Bernardo [UNIFESP], Omori, Ichiro M., Fenton, Mark   +3 more
core   +1 more source