Results 151 to 160 of about 32,295 (302)

Effectiveness of deep brain stimulation in alleviating treatment-resistant schizophrenia: a systematic review

European Journal of Translational Myology
The complexity of schizophrenia, particularly in cases resistant to traditional pharmacological treatments, poses significant challenges for clinicians and researchers.
Mohsen Khosravi
doaj   +1 more source

‘Liberation’ of ‘Younger Brothers’ or Genocide of Subhumans? Genocidal Discourses on Ukrainians in Putin's Regime

Nations and Nationalism, EarlyView.
ABSTRACT This article explores Russia's genocidal discourses on Ukrainians, focusing on the predominant narrative that frames cultural genocide as the ‘liberation’ of Ukrainians through the erasure of their cultural identity. Existing literature tends to overlook this form of genocidal discourse, which diverges from typical ‘othering’ by instead ...
Martin Laryš
wiley   +1 more source

Differential Neuronal Development in iPSC-Derived Neural Stem Cells From Monozygotic Twin Cases With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine. [PDF]

Neuropsychopharmacol Rep
We investigated early neuronal development using iPSCs from twins with treatment‐resistant schizophrenia discordant for clozapine response. The non‐responder exhibited more pronounced impairment in differentiation than the responder. Transcriptomic analysis revealed distinct developmental gene expression profiles, suggesting that early ...
Kawano S, Katayama S, Ogawa M, Endo R, Ikeda N, Ikeuchi Y, Mita T, Takei H, Gotoda-Nishimura N, Miura D, Fukushima H, Hashimoto H, Hashimoto R, Nakazawa T.   +13 more
europepmc   +2 more sources

The Causal Role of Adiposity in Mental Illness: A Systematic Review and Meta‐Analysis of Mendelian Randomization Studies

Obesity Reviews, EarlyView.
ABSTRACT Objective This study aimed to examine the causal effect of adiposity on mental illnesses by summarizing and assessing evidence from Mendelian randomization (MR) studies. Method Searches were conducted on Embase, Medline, and Web of Science from database inception to September 22nd, 2025.
Min Gao, Paul J. Doody, Dimitrios A. Koutoukidis, Yebo Yu, Paul Aveyard, Richard Stevens, Padraig C. Dixon   +6 more
wiley   +1 more source

Radical dystopia: The comic modernism of George Orwell's Nineteen Eighty‐Four

Orbis Litterarum, EarlyView.
Abstract The present essay turns the received view of George Orwell's Nineteen Eighty‐Four on its head, arguing that Orwell's dystopian classic mobilizes the modernist techniques of T. S. Eliot's The Waste Land to lampoon the ideological fatalism of Eliot and other cultural conservatives.
Magnus Ullén
wiley   +1 more source

The Anterolateral Transpedicular Transverse Process Screw Technique: Surgical Techniques, Biomechanical study and Preliminary Outcomes

Orthopaedic Surgery, EarlyView.
This study designed a novel anterolateral screw placement technique and, based on this, developed a new anterolateral fixation method. Imaging, biomechanical, and short‐term efficacy analyses revealed that the Anterolateral Transpedicular Transverse Process Screw (ALTTS) technique achieves a high success rate for L5 vertebral fixation (pedicle width ...
Mingdong Zhang, Jiaqi Wang, Jin Chu, Xin Guo, Wei Zhang, Dapeng Feng, Zhengwei Li   +6 more
wiley   +1 more source

Treatment resistant schizophrenia in Slovenian population

Zdravniški Vestnik, 2014
Background. Approximately 30 % of patients with schizophrenia do not achieve remission upon antipsychotic treatment. The purpose of this article is to present the differences between treatment resistant and treatment responsive patients in Slovenian ...
Tea Terzić, Vita Dolžan, Matej Kastelic, Blanka Kores Plesničar   +3 more
doaj  

Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda, Matteo Martino, Nhi Thao Ngoc Le, Wen‐Yin Chen, Ming‐Chyi Huang, David Blum, Thierry Burnouf   +6 more
wiley   +1 more source

Association between initial 30‐day cumulative clozapine dose and risk of agranulocytosis: A nationwide register‐based cohort study

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Clozapine‐induced agranulocytosis (CIA) is traditionally considered an idiosyncratic, dose‐independent reaction. However, emerging evidence suggests that clozapine‐related inflammatory events may exhibit dose‐dependent characteristics, leading us to hypothesize that CIA risk may similarly relate to early cumulative exposure.
Yuki Kikuchi, Xue Li, Hiroshi Komatsu, Norio Yasui‐Furukori, Ken Inada, Hiroaki Tomita   +5 more
wiley   +1 more source

A Randomized Clinical Trial of Group Cognitive-Rehabilitation Therapy for Patients with Schizophrenia Resistant to Medication

Iranian Rehabilitation Journal, 2008
Objectives: Against the background of evidence-based treatments for schizophrenia resistant to medication, the implementation of cognitive-Rehabilitation therapy (CRT) becomes more important, especially about patients who don’t response to ...
Neda Ali beigi, Parvaneh Mohammadkhani, Robabeh Mazinani, Behrooz Doolatshahi   +3 more
doaj