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TREATMENT OF RESISTANT AND ULTRA RESISTANT SCHIZOPHRENIA

Psychiatria Danubina, 2021
Schizophrenia is a psychiatric disease which affects one percent of population. It is most common in young adults. It is primarily treated with typical and atypical antipsychotics. Resistant schizophrenia is a condition diagnosed after no response is noticed to two different antipsychotics of which one is atypical.
Medić, Antonija, Herceg, Dora, Herceg, Miroslav   +2 more
openaire   +7 more sources

Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia. [PDF]

Schizophr Bull
Background and Hypothesis Disorganized thinking is a prominent feature of schizophrenia that becomes persistent in the presence of treatment resistance.
Huang H, Qin X, Xu R, Xiong Y, Hao K, Chen C, Wan Q, Liu H, Yuan W, Peng Y, Zhou Y, Wang H, Palaniyappan L.   +12 more
europepmc   +2 more sources

Obsessive-compulsive symptoms in patient with schizophrenia: The influence of disorganized symptoms, duration of schizophrenia, and drug resistance

Frontiers in Psychiatry, 2023
BackgroundSchizophrenia is a chronic mental disorder with a many-faced clinical presentation. Obsessive–compulsive symptoms are often part of it. The characteristics of the clinical picture and the course of schizophrenia are factors related to both the ...
Georgi Panov, Georgi Panov, Presyana Panova   +2 more
doaj   +1 more source

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

eLife, 2021
We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resistant ...
Eilis Hannon, Emma L Dempster, Georgina Mansell, Joe Burrage, Nick Bass, Marc M Bohlken, Aiden Corvin, Charles J Curtis, David Dempster, Marta Di Forti, Timothy G Dinan, Gary Donohoe, Fiona Gaughran, Michael Gill, Amy Gillespie, Cerisse Gunasinghe, Hilleke E Hulshoff, Christina M Hultman, Viktoria Johansson, René S Kahn, Jaakko Kaprio, Gunter Kenis, Kaarina Kowalec, James MacCabe, Colm McDonald, Andrew McQuillin, Derek W Morris, Kieran C Murphy, Colette J Mustard, Igor Nenadic, Michael C O'Donovan, Diego Quattrone, Alexander L Richards, Bart PF Rutten, David St Clair, Sebastian Therman, Timothea Toulopoulou, Jim Van Os, John L Waddington, Wellcome Trust Case Control Consortium (WTCCC), CRESTAR consortium, Patrick Sullivan, Evangelos Vassos, Gerome Breen, David Andrew Collier, Robin M Murray, Leonard S Schalkwyk, Jonathan Mill   +47 more
doaj   +1 more source

Resistant schizophrenia in a patient with oculocutaneous albinism successfully treated with clozapine

European Psychiatry, 2022
Introduction Several studies have shown an association between oculocutaneous albinism and several neuropsychiatric entities, including schizophrenia.
A. Jelti, F. N’Sabi, F. Kennab, M. Barrimi   +3 more
doaj   +1 more source

Difference between treatment-resistant schizophrenia and clozapine-resistant schizophrenia

World Journal of Psychiatry, 2022
We read the impressive review article "Clozapine resistant schizophrenia: Newer avenues of management" with great enthusiasm and appreciation. The author believes that preventing clozapine resistance from developing may be the most effective treatment strategy for patients with clozapine-resistant schizophrenia (CRS), and optimizing clozapine treatment
Tseng, Ping-Tao, Chen, Mu-Hong, Liang, Chih-Sung   +2 more
openaire   +2 more sources

Treatment resistance in schizophrenia [PDF]

BMJ, 1996
Alternative drugs may offer clearer understanding of underlying mechanisms Since the 1950s, when chlorpromazine was introduced into psychiatric practice, antipsychotic drugs have been the cornerstone of the management of schizophrenia. They have three main functions: to treat the positive symptoms of acute schizophrenic episodes; to reduce ...
E C, Johnstone, R, Sandler
openaire   +2 more sources

Treatment of early resistant schizophrenia: a case report

European Psychiatry, 2023
Introduction Early-onset schizophrenia begins before the age of 18. Drug treatments are mainly based on antipsychotics, preferably atypical antipsychotics, which have fewer side effects compared to first generation antipsychotics.
S. Benhammou, M. Raissouni, H. Kisra
doaj   +1 more source

An international research agenda for clozapine-resistant schizophrenia [PDF]

, 2023
Treatment-resistant symptoms occur in about a third of patients with schizophrenia and are associated with a substantial reduction in their quality of life.
Hasan, Alkomiet, Correll, Christoph U, Endres, Dominique, Gonzalez-Diaz, Jairo M, Guloksuz, Sinan, Guu, Ta-Wei, van Dellen, Edwin, Wagner, Elias, Sommer, Iris E, DeLisi, Lynn E, Takahashi, Shun, Shiers, David, Chadly, Zohra, Luykx, Jurjen J, Siskind, Dan, Mhalla, Ahmed, Lee, Jimmy, Chan, Sherry K W, Cotes, Robert O, MacCabe, James, Tiihonen, Jari, Boks, Marco P, Every-Palmer, Susanna, van der Horst, Marte Z, Benros, Michael E, Cummins, Russel   +25 more
core   +3 more sources

Identifying treatment-resistant schizophrenia [PDF]

British Journal of Psychiatry, 2013
I was surprised to read the paper of Howes et al .[1][1] No control group was investigated. This paper implies that any patient for whom a third antipsychotic is considered ought to be considered for clozapine, and if they are not started on clozapine, this constitutes an unacceptable delay.
Kiriakos, Xenitidis, Colin, Campbell, Ann, Mortimer   +2 more
openaire   +2 more sources