Treatment-Resistant Schizophrenia
Although, gratifyingly, research on the treatment of schizophrenia has increasingly focused on first-episode and prodromal patient populations, it is still recognized that many patients with more chronic illnesses exhibit a suboptimal response to treatments.
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Electroconvulsive Therapy for Treatment-Resistant Schizophrenia [PDF]
Electroconvulsive therapy (ECT) involves the induction of a seizure by the administration of an electrical stimulus via electrodes usually placed bilaterally on the scalp and was introduced as a treatment for schizophrenia in 1938. However, ECT is a controversial treatment with concerns about long-term side effects such a memory loss.
Diarmid J M, Sinclair +5 more
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Metacognitive Therapy in Treatment-Resistant Psychosis:A Multiple-Baseline Study [PDF]
Background: More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression.
Wardle, Melissa +8 more
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Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia [PDF]
Treatment-resistant schizophrenia (TRS) affects around one-third of individuals with schizophrenia. Although a number of sociodemographic and clinical predictors of TRS have been identified, data on the genetic risk of TRS are sparse. We aimed to investigate the association between a polygenic risk score for schizophrenia and treatment resistance in ...
Wimberley, Theresa +5 more
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Electroconvulsive therapy combined with clozapine in the management of ultra-resistant schizophrenia
Introduction Although clozapine is the gold standard for treating patients with resistant schizophrenia, clinical symptoms persist in approximately 40-70% of the cases even after a year of treatment with clozapine.
S. Khouadja +3 more
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Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics [PDF]
There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks.
Buckley, P +45 more
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BackgroundThis study aimed to conduct a systematic review and meta-analysis on cognitive performances of patients with treatment-resistant schizophrenia (TRS) after clozapine treatment and to examine the potential effect of follow-up duration and ...
Sherry Kit Wa Chan +13 more
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Clozapine combination and augmentation strategies in patients with schizophrenia: recommendations from an international expert survey among the Treatment Response and Resistance in Psychosis (TRRIP) Working Group [PDF]
Evidence for the management of inadequate clinical response to clozapine in treatment-resistant schizophrenia is sparse. Accordingly, an international initiative was undertaken with the aim of developing consensus recommendations for treatment strategies
Schneider-Axmann, Thomas +10 more
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Cariprazine: Patients with Treatment-Resistant Schizophrenia
Thomas Aubel Kliniken Essen-Mitte, Klinik für Psychiatrie, Psychotherapie, Psychosomatik und Suchtmedizin, Essen, GermanyCorrespondence: Thomas AubelKliniken Essen-Mitte, Klinik für Psychiatrie, Psychotherapie, Psychosomatik und Suchtmedizin ...
Aubel T
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