Results 231 to 240 of about 32,295 (302)

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

Associations between glutamate and cerebral blood flow in treatment-resistant schizophrenia during clozapine treatment. [PDF]

J Psychopharmacol
Sun J, Zelaya F, Sendt KV, McQueen G, Gillespie AL, Lally J, O'Daly O, Lythgoe DJ, Howes OD, Barker GJ, McGuire P, MacCabe JH, Egerton A.   +12 more
europepmc   +1 more source

Learning Outcomes That Maximally Differentiate Psychiatric Treatments

International Journal of Methods in Psychiatric Research, Volume 35, Issue 2, June 2026.
ABSTRACT Objectives To develop a statistical method that uncovers clinically meaningful differences between active psychiatric treatments, even when traditional rating scales fail to do so. Methods We introduce Supervised Varimax (SV), a novel algorithm that transforms individual items from clinical rating scales into a small set of optimized outcomes ...
Eric V. Strobl, Semmie Kim
wiley   +1 more source

Exploring High-Dose Olanzapine for Psychosis in an Adolescent With Treatment-Resistant Schizophrenia. [PDF]

Cureus
Aggarwal S, Sahu SP, Shah P, Knobles MJ.
europepmc   +1 more source

Association Between Psychiatrists' Subjective Clinical Behavior Scores and Objective Quality Indicators Based on Discharge Prescriptions: A Nationwide Multicenter Study Based on the EGUIDE Project

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Association between quality indicators and clinical behaviors related to the guidelines for schizophrenia. ABSTRACT Aim Psychiatrists often perceive their clinical practices as guideline‐concordant; however, discrepancies frequently exist between perceived and actual prescribing behaviors.
Kazuhiko Yamamuro, Naomi Hasegawa, Yusuke Arai, Hikaru Hori, Hiroyuki Muraoka, Toru Horinouchi, Naoki Hashimoto, Shinichiro Ochi, Takashi Tsuboi, Hirotaka Yamagata, Junya Matsumoto, Satsuki Ito, Toshiaki Onitsuka, Kazutaka Ohi, Hisashi Yamada, Jun‐ichi Iga, Ken Inada, Koichiro Watanabe, Norio Yasui‐Furukori, Ryota Hashimoto   +19 more
wiley   +1 more source

Transcranial Calcium Macro‐Imaging From the Auditory Cortex of Thy1‐Cre‐Driven GCaMP8 Transgenic Rats

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We generated Thy1‐Cre–driven GCaMP8 transgenic rats by mating Thy1‐Cre rats with knock‐in rats carrying a floxed GCaMP8‐STOP cassette in the β‐actin locus. Robust neuronal GCaMP8 expression enabled transcranial calcium imaging of the auditory cortex, establishing this model as a powerful tool for minimally invasive cortical macro‐imaging and functional
Manavu Tohmi, Hisaaki Namba, Meiko Kawamura, Ryuichi Hishida, Shota Iguchi, Kazuto Kobayashi, Natsuki Matsushita, Tomoji Mashimo, Rie Natsume, Kenji Sakimura, Hiroyuki Nawa   +10 more
wiley   +1 more source

Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N‐Desmethyl and N‐Oxide Metabolites in a Japanese Patient With Schizophrenia

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
In a Japanese patient with schizophrenia, the effects of repeated smoking and quitting cigarettes on plasma concentrations of clozapine (CLZ) and its major metabolites, N‐desmethyl clozapine (NCLZ) and N‐oxide clozapine (OCLZ), were shown to be reproducible. ABSTRACT Clozapine (CLZ) is used for treatment‐resistant schizophrenia.
Kazuro Ikawa, Norifumi Morikawa, Mutsumi Sakata, Naoki Horikawa   +3 more
wiley   +1 more source

Peripheral biomarkers and the philosophy of precision in treatment-resistant schizophrenia. [PDF]

Neurosci Appl
Jerotic S.
europepmc   +1 more source