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Schizophrenia Bulletin, 2021 Studies on the long-term development and early predictors of treatment-resistant schizophrenia (TRS) and clozapine-resistant TRS (CR-TRS) in patients with first-episode schizophrenia-spectrum disorders (FES) are limited and have not considered the impact
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A Case of Resistant Schizophrenia
British Journal of Psychiatry, 1986In an era when it is generally believed that the acute Symptoms of schizophrenia can be controlled pharmacologically, the case of a young man who has remained almost continuously floridly psychotic for 13 years, despite treatment, is disquieting. Conventional psychiatrie treatment appears to be rendered impotent. It is in this context that it may be of
J E, Roberts +6 more
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Treatment-Resistant Schizophrenia
Psychiatric Clinics of North America, 2016Although treatment-resistant schizophrenia (TRS) was described 50 years ago and has a gold standard treatment with clozapine based on well-defined criteria, there is still a matter of great interest and controversy. In terms of the underlying mechanisms of the development of TRS, progress has been made for the elucidation of the neurochemical ...
Helio, Elkis, Peter F, Buckley
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Treatment-Resistant Schizophrenia
Psychiatric Clinics of North America, 2007This article opens with a brief history of pharmacologic treatment of schizophrenia. It then discusses the definition and treatment of treatment-resistant schizophrenia, with particular attention to clinical, biological and neuroimaging correlates, as well as the best treatment options, including the use of clozapine in patients who meet the definition
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